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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
medicine
Hypovitaminosis D is common among pulmonary tuberculosis patients in Tanzania but is not explained by the acute phase response
Journal of Nutrition, Volume 138, No. 12, Year 2008
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Description
Vitamin D is essential to immune function, but little is known about the vitamin D status in equatorial populations. A crosssectional study was conducted among pulmonary tuberculosis (PTB) patients in Mwanza, Tanzania to identify the predictors of their vitamin D status. Data on sociodemography, season, and intake of food, alcohol, tobacco, and soil were collected, anthropometric measurements taken, and serum α1-antichymotrypsin (ACT), ferritin and soluble transferrin receptor (sTfR), and serum 25-hydroxy- (ergocalciferol1cholecalciferol) [25(OH)D] determined. Of the 655 patients studied, 79.7% (508/637) were culture-positive (PTB+) and 47.2% HIV infected. Mean serum ACT, an acute phase reactant, was 0.73 ± 0.25 g/L with 69.2% >0.6 g/L. Mean serum 25(OH)D was 86.6 ± 32.9 nmol/L, with 41.2% <75 nmol/L. Serum 25(OH)D was highest during the harvest season, May to July, compared with the remaining year. Single subjects had lower [10.4 (95% CI 4.0; 16.9) nmol/L] serum 25(OH)D concentrations than married subjects and PTB+ patients had concentrations lower [8.2 (95% CI 1.5; 14.9) nmol/L] than PTB- patients. Serum 25(OH)D increased with consumption of a large freshwater fish but not of small dried fish or other foods. BMI and serum TfR were positive predictors of serum 25(OH)D, whereas neither elevated serum ACT nor HIV were predictors. In conclusion, serum 25(OH)D is a valid measure of vitamin D status during the acute phase response. The lower concentrations in PTB+ patients may reflect lower sun exposure or increased utilization. The health consequences of hypovitaminosis D in low-income equatorial populations, at risk for both infectious and chronic diseases, should be studied. © 2008 American Society for Nutrition.
Authors & Co-Authors
Friis, Henrik M.U.
Denmark, Frederiksberg
Det Natur- og Biovidenskabelige Fakultet
Range, Nyagosya Segere
Tanzania, Tanga
National Institute for Medical Research Tanga
Pedersen, Marianne L.
Denmark, Frederiksberg
Det Natur- og Biovidenskabelige Fakultet
Molgaard, C.
Denmark, Frederiksberg
Det Natur- og Biovidenskabelige Fakultet
Changalucha, John M.
Tanzania, Tanga
National Institute for Medical Research Tanga
Krarup, Henrik B.
Denmark, Aalborg
Aalborg Universitetshospital
Magnussen, Pascal
Denmark, Copenhagen
Dbl -center for Health Research and Development
Soborg, Christian
Denmark, Copenhagen
Københavns Universitet
Andersen, Åse Bengård
Denmark, Copenhagen
Københavns Universitet
Statistics
Citations: 80
Authors: 9
Affiliations: 5
Identifiers
Doi:
10.3945/jn.108.094979
ISSN:
00223166
Research Areas
Food Security
Infectious Diseases
Substance Abuse
Study Locations
Tanzania