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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
immunology and microbiology
Clinical study comparing probiotic Lactobacillus GR-1 and RC-14 with metronidazole vaginal gel to treat symptomatic bacterial vaginosis
Microbes and Infection, Volume 8, No. 12-13, Year 2006
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Description
Bacterial vaginosis (BV) is particularly common in black women, and in Nigeria it is often caused by Mycoplasma, as well as Atopobium, Prevotella and Gardnerella sp. Antimicrobial metronidazole oral therapy is poorly effective in eradicating the condition and restoring the Lactobacillus microbiota in the vagina. In this study, 40 women diagnosed with BV by discharge, fishy odor, sialidase positive test and Nugent Gram stain scoring, were randomized to receive either two dried capsules containing Lactobacillus rhamnosus GR-1 and Lactobacillus reuteri RC-14 each night for 5 days, or 0.75% metronidazole gel, applied vaginally twice a day (in the morning and evening). Follow-up at day 6, 15 and 30 showed cure of BV in significantly more probiotic treated subjects (16, 17 and 18/20, respectively) compared to metronidazole treatment (9, 9 and 11/20: P = 0.016 at day 6, P = 0.002 at day 15 and P = 0.056 at day 30). This is the first report of an effective (90%) cure of BV using probiotic lactobacilli. Given the correlation between BV and HIV, and the high risk of the latter in Nigeria, intravaginal use of lactobacilli could provide women with a self-use therapy, similar to over-the-counter anti-yeast medication, for treatment of urogenital infections. © 2006 Elsevier Masson SAS. All rights reserved.
Authors & Co-Authors
Anukam, Kingsley
Nigeria, Benin
University of Benin
Nigeria, Benin
Chidak Medical Diagnostic Laboratories
Nigeria, Benin
Benson Idahosa University
Osazuwa, Emmanuel O.
Nigeria, Benin
University of Benin
Osemene, Gibson I.
Nigeria, Benin
Benin City/military Base Hospital
Ehigiagbe, Felix
Nigeria, Benin
University of Benin
Bruce, Andrew W.
Canada, London
Lawson Health Research Institute
Reid, Gregor
Canada, London
Lawson Health Research Institute
Canada, London
Western University
Statistics
Citations: 6
Authors: 6
Affiliations: 6
Identifiers
Doi:
10.1016/j.micinf.2006.08.008
ISSN:
12864579
e-ISSN:
1769714X
Research Areas
Health System And Policy
Infectious Diseases
Study Design
Cohort Study
Study Locations
Nigeria
Participants Gender
Female