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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
medicine
Single Site Experience of the use of Monoclonal Antibodies for the Treatment of COVID-19 in High-risk Pediatric and Young Adult Patients
Pediatric Infectious Disease Journal, Volume 41, No. 12, Year 2022
Notification
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Description
Background: Effective therapeutic agents for the treatment of COVID-19 have been investigated since the onset of the pandemic. Monoclonal antibodies targeting the spike protein of SARS-CoV-2 have been developed for the treatment of mild or moderate COVID disease in high-risk populations. Despite widespread use in the adult population, data are limited on the safety and efficacy of monoclonal antibody infusions in the adolescent and young adult population. Methods: Patients who received bamlanivimab, bamlanivimab-etesevimab, casirivimab-imdevimab, or sotrovimab for treatment of mild-to-moderate COVID-19 disease at Cincinnati Children's Hospital Medical Center from 5/1/2020 to 3/1/2022 were identified retrospectively. Patient data including demographics, adverse events, and outcomes were extracted from patients' charts and summarized by standard descriptive summaries. Results: Ninety-four patients received monoclonal antibody therapy, of which 14 (14.9%) received either bamlanivimab or bamlanivimab-etesevimab, 54 (57.4%) received casirivimab-imdevimab, and 26 (27.6%) received sotrovimab. Ten patients (10.6%) experienced one or more infusion-related adverse event. Of the patients who experienced adverse events, all resolved with cessation of infusion. No life-threatening events or deaths occurred. Within 90 days of receiving a monoclonal antibody, 12 patients (12.7%) required additional medical care for ongoing COVID symptoms. Five of these were either hospitalized or received escalation of care while already in the hospital. All subsequently fully recovered. Neither infusion-related adverse events nor progression to hospitalization for ongoing COVID-19 symptoms following monoclonal antibody administration were associated with any particular underlying condition. Conclusions: Overall, monoclonal antibodies are reasonably well-tolerated COVID-19 therapies in high-risk adolescent and young adult populations. © 2022 Lippincott Williams and Wilkins. All rights reserved.
Authors & Co-Authors
Frenck, Robert W.
United States, Cincinnati
Cincinnati Children's Hospital Medical Center
United States, Cincinnati
University of Cincinnati
Grimley, Michael S.
United States, Cincinnati
University of Cincinnati
United States, Cincinnati
Cincinnati Children's Hospital Medical Center
Marsh, Rebecca A.
United States, Cincinnati
University of Cincinnati
United States, Cincinnati
Cincinnati Children's Hospital Medical Center
Paulsen, Grant C.
United States, Cincinnati
Cincinnati Children's Hospital Medical Center
United States, Cincinnati
University of Cincinnati
Haslam, David B.
United States, Cincinnati
Cincinnati Children's Hospital Medical Center
United States, Cincinnati
University of Cincinnati
Spearman, Paul W.
United States, Cincinnati
Cincinnati Children's Hospital Medical Center
United States, Cincinnati
University of Cincinnati
Schulert, Grant S.
United States, Cincinnati
University of Cincinnati
United States, Cincinnati
Cincinnati Children's Hospital Medical Center
Danziger-Isakov, Lara A.
United States, Cincinnati
Cincinnati Children's Hospital Medical Center
United States, Cincinnati
University of Cincinnati
Statistics
Citations: 3
Authors: 8
Affiliations: 2
Identifiers
Doi:
10.1097/INF.0000000000003703
ISSN:
08913668
Research Areas
Covid
Health System And Policy
Maternal And Child Health
Study Design
Cross Sectional Study