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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
medicine
Effect of male circumcision on the prevalence of high-risk human papillomavirus in young men: Results of a randomized controlled trial conducted in orange farm, South Africa
Journal of Infectious Diseases, Volume 199, No. 1, Year 2009
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Description
Background. A causal association links high-risk human papillomavirus (HR-HPV) and cervical cancer, which is a major public health problem. The objective of the present study was to investigate the association between male circumcision (MC) and the prevalence of HR-HPV among young men. Methods. We used data from a MC trial conducted in Orange Farm, South Africa, among men aged 18-24 years. Urethral swab samples were collected during a period of 262 consecutive days from participants in the intervention (circumcised) and control (uncircumcised) groups who were reporting for a scheduled follow-up visit. Swab samples were analyzed using polymerase chain reaction. HR-HPV prevalence rate ratios (PRRs) were assessed using univariate and multivariate log Poisson regression. Results. In an intention-to-treat analysis, the prevalences of HR-HPV among the intervention and control groups were 14.8% (94/637) and 22.3% (140/627), respectively, with a PRR of 0.66 (0.51-0.86) (P = .002). Controlling for propensity score and confounders (ethnic group, age, education, sexual behavior [including condom use], marital status, and human immunodeficiency virus status) had no effect on the results. Conclusions. This is the first randomized controlled trial to show a reduction in the prevalence of urethral HR-HPV infection after MC. This finding explains why women with circumcised partners are at a lower risk of cervical cancer than other women. Trial registration. ClinicalTrials.gov identifier: NCT00122525. © 2008 by the Infectious Diseases Society of America. All rights reserved.
Authors & Co-Authors
Auvert, Bertran
France, Versailles
Université de Versailles Saint-quentin-en-yvelines
France, Paris
Inserm
Sobngwi-Tambekou, Jöelle Laure
France, Paris
Inserm
Cutler, Ewaldé
South Africa, Johannesburg
National Institute for Communicable Diseases
Nieuwoudt, Marthi
South Africa, Johannesburg
National Institute for Communicable Diseases
Lissouba, Pascale
France, Paris
Inserm
Puren, Adrian
South Africa, Johannesburg
National Institute for Communicable Diseases
Taljaard, Dirk J.
South Africa, Johannesburg
Progressus
Statistics
Citations: 297
Authors: 7
Affiliations: 4
Identifiers
Doi:
10.1086/595566
ISSN:
00221899
Research Areas
Cancer
Sexual And Reproductive Health
Study Design
Randomised Control Trial
Cross Sectional Study
Cohort Study
Study Approach
Quantitative
Study Locations
South Africa
Participants Gender
Male
Female