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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
Identification of prognosis markers in pediatric high-risk acute lymphoblastic leukemia
Pediatric Hematology and Oncology, Volume 22, No. 7, Year 2005
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Description
Gene expression profiling may improve the understanding of the biology behind relapse in pediatric acute lymphoblastic leukemia. Using suppression subtractive hybridization (SSH), cDNA concatenated sequencing (CCS), and reverse transcriptase real-time quantitative polymerase chain reaction (RT-RQ-PCR) on high-risk patient samples with nondeterminant chromosomal translocation, the authors identified 3 genes that were significantly overexpressed in the nonrelapsed patients: the calcium/calmodulin-dependent serine protein kinase (CASK), subunit 2 of the cofactor required for SP1 transcriptional activation (CRSP2), and granzyme K (GZMK). The level of expression of these biomarkers may help identify patients with potentially good prognosis within a group otherwise at high risk of relapse. Copyright © Taylor and Francis Inc.
Authors & Co-Authors
Al-Lamki, Zakia M.N.
Oman, Muscat
Sultan Qaboos University
Wali, Y. Ahmed
Oman, Muscat
Sultan Qaboos University
Zachariah, Mathew
Oman, Muscat
Sultan Qaboos University
Al-Kharusi, Khalsa
Oman, Muscat
Sultan Qaboos University
Gunaratne, Preethi H.
United States, Houston
Baylor College of Medicine
Gibbs, Richard A.L.
United States, Houston
Baylor College of Medicine
Gingras, Marie Claude
United States, Houston
Texas Children's Cancer Center and Hematology Service
Margolin, Judith Frances
United States, Houston
Texas Children's Cancer Center and Hematology Service
United States, Houston
Texas Children's Hospital
Statistics
Citations: 4
Authors: 8
Affiliations: 4
Identifiers
Doi:
10.1080/08880010500199069
ISSN:
15210669
Research Areas
Genetics And Genomics
Health System And Policy
Study Approach
Quantitative