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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
chemistry
Gated mesoporous silica nanoparticles using a double-role circular peptide for the controlled and target-preferential release of doxorubicin in CXCR4-expresing lymphoma cells
Advanced Functional Materials, Volume 25, No. 5, Year 2015
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Description
B-cell non-Hodgkin's lymphoma (B-NHL) is the most frequent malignant lymphoid neoplasm, which has a high degree of relapse and chemoresistance. Thus, strategies to improve currently used therapies are needed. In this context, a new CXCR4-targeted delivery system is described using mesoporous silica nanoparticles (MSNs) that are loaded with doxorubicin and capped with a derivative of the T22 peptide ( P ). This design makes full use of the great affi nity of the T22 peptide to CXCR4 receptor, which is overexpressed in lymphoma cells. The peptide is able to guide the gated nanoparticle to B-NHL cells to facilitate MSNs uptake via the CXCR4 receptor. The endocyted P -capped MSNs are also opened by endosomal proteolytic enzymes to allow intracellular doxorubicin delivery. © 2014 WILEY-VCH Verlag GmbH & Co. KGaA,Weinheim.
Authors & Co-Authors
Acosta, Gerardo A.
Spain, Madrid
Centro de Investigación Biomédica en Red de Bioingeniería, Biomateriales y Nanomedicina
Alberício, Fernando
Spain, Madrid
Centro de Investigación Biomédica en Red de Bioingeniería, Biomateriales y Nanomedicina
Spain, Barcelona
Universitat de Barcelona
Ecuador, Quito
Yachay University for Experimental Technology and Research Yachay Tech
Royo, Míriam
Spain, Madrid
Centro de Investigación Biomédica en Red de Bioingeniería, Biomateriales y Nanomedicina
Martínez-Máñez, Ramón
Spain, Madrid
Centro de Investigación Biomédica en Red de Bioingeniería, Biomateriales y Nanomedicina
Statistics
Citations: 54
Authors: 4
Affiliations: 3
Identifiers
Doi:
10.1002/adfm.201403822
ISSN:
1616301X
Research Areas
Cancer