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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
medicine
A randomized comparative study of esomeprazole 40 mg versus pantoprazole 40 mg for healing erosive oesophagitis: The EXPO study
Alimentary Pharmacology and Therapeutics, Volume 21, No. 6, Year 2005
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Description
Aim: To assess the efficacy of the 8-week therapy with esomeprazole 40 mg vs. pantoprazole 40 mg for healing erosive oesophagitis (EE) as part of a management study. Methods: Patients had a history of gastro-oesophageal reflux disease symptoms (≥6 months) and had suffered heartburn on at least 4 of the 7 days preceding enrolment. Endoscopies were performed to grade EE severity using the Los Angeles (LA) classification system at baseline, 4 and 8 weeks (if unhealed at 4 weeks). Heartburn severity was recorded by patients on diary cards. The primary end point was healing of EE by week 8 of treatment. Results: Of 3170 patients randomized, the intent-to-treat population consisted of 3151 patients (63% male, mean age: 50.6 years, 27% Helicobacter pylori-positive). Esomeprazole 40 mg healed a significantly greater proportion of EE patients than pantoprazole 40 mg at both 4 weeks (life table estimates: esomeprazole 81%, pantoprazole 75%, P < 0.001) and 8 weeks (life table estimates; esomeprazole 96%, pantoprazole 92%, P < 0.001). The median time to reach sustained heartburn resolution was 6 days in patients receiving esomeprazole and 8 days with pantoprazole (P < 0.001). Conclusion: Esomeprazole 40 mg is more effective than pantoprazole 40 mg for healing EE and providing resolution of associated heartburn. © 2005 Blackwell Publishing Ltd.
Authors & Co-Authors
Labenz, Joachim
Germany, Siegen
Ev. Jung-stilling-krankenhaus Ggmbh
Armstrong, D.
Canada, Hamilton
Mcmaster University Medical Centre
Lauritsen, K.
Denmark, Odense
Odense Universitetshospital
Katelaris, P.
Australia, Sydney
The University of Sydney
Schmidt, S.
South Africa, Cape Town
Burnside House
Schütze, K.
Austria, Vienna
Hanusch-krankenhaus
Wallner, G.
Poland, Lublin
Medical University of Lublin
Juergens, H.
Germany
Gastroenterology Specialist Centre
Preiksaitis, H.
Canada, London
Western University
Keeling, N.
Sweden, Sodertalje
Astrazeneca Sweden
Nauclér, Emma C.
Sweden, Sodertalje
Astrazeneca Sweden
Eklund, S.
Sweden, Sodertalje
Astrazeneca Sweden
Statistics
Citations: 150
Authors: 12
Affiliations: 10
Identifiers
Doi:
10.1111/j.1365-2036.2005.02368.x
ISSN:
02692813
Study Design
Cross Sectional Study
Participants Gender
Male