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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
general
No evidence of XMRV or related retroviruses in a london HIV-1-positive patient cohort
PLoS ONE, Volume 6, No. 3, Article e18096, Year 2011
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Description
Background: Several studies have implicated a recently discovered gammaretrovirus, XMRV (Xenotropic murine leukaemia virus-related virus), in chronic fatigue syndrome and prostate cancer, though whether as causative agent or opportunistic infection is unclear. It has also been suggested that the virus can be found circulating amongst the general population. The discovery has been controversial, with conflicting results from attempts to reproduce the original studies. Methodology/Principal Findings: We extracted peripheral blood DNA from a cohort of 540 HIV-1-positive patients (approximately 20% of whom have never been on anti-retroviral treatment) and determined the presence of XMRV and related viruses using TaqMan PCR. While we were able to amplify as few as 5 copies of positive control DNA, we did not find any positive samples in the patient cohort. Conclusions/Significance: In view of these negative findings in this highly susceptible group, we conclude that it is unlikely that XMRV or related viruses are circulating at a significant level, if at all, in HIV-1-positive patients in London or in the general population. © 2011 Gray et al.
Authors & Co-Authors
Gray, Eleanor R.
United Kingdom, London
University College London
Garson, Jeremy A.
United Kingdom, London
University College London
Breuer, Judith M.
United Kingdom, London
University College London
Edwards, Simon G.
United Kingdom, London
University College London
Kellam, P.
United Kingdom, London
University College London
United Kingdom, Hinxton
Wellcome Sanger Institute
Morris, Lynn G.
United Kingdom, London
University College London
Towers, Greg J.
United Kingdom, London
University College London
Statistics
Citations: 26
Authors: 7
Affiliations: 2
Identifiers
Doi:
10.1371/journal.pone.0018096
ISSN:
19326203
Research Areas
Cancer
Genetics And Genomics
Health System And Policy
Infectious Diseases
Study Design
Cross Sectional Study
Cohort Study