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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
immunology and microbiology
Risk factors for African tick-bite fever in rural central Africa
American Journal of Tropical Medicine and Hygiene, Volume 84, No. 4, Year 2011
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Description
African tick-bite fever is an emerging infectious disease caused by the spotted fever group Rickettsia, Rickettsia africae, and is transmitted by ticks of the genus Amblyomma. To determine the seroprevalence of exposure to R. africae and risk factors associated with infection, we conducted a cross-sectional study of persons in seven rural villages in distinct ecological habitats of Cameroon. We examined 903 plasma samples by using an indirect immunofluorescence assay for antibodies to R. africae and analyzed demographic and occupational data collected from questionnaires. Of the 903 persons tested, 243 (26.9%) had IgG/IgM/IgA reactive with R. africae. Persons from four of the seven village sites were significantly more likely to be seropositive (P < 0.05), and lowland forest sites tended to have higher seroprevalences. These results suggest that African tick-bite fever is common in adults in rural areas of Cameroon and that ecological factors may play a role in the acquisition of R. africae infection. Copyright © 2011 by The American Society of Tropical Medicine and Hygiene.
Authors & Co-Authors
Ndip, Lucy Mande
Cameroon, Buea
University of Buea
Biswas, Hope H.
United States, Baltimore
Johns Hopkins Bloomberg School of Public Health
Nfonsam, Landry E.
Cameroon, Buea
University of Buea
LeBreton, Matthew
Cameroon, Yaounde
Johns Hopkins Cameroon Program
Ndip, Roland
South Africa, Alice
University of Fort Hare
Bissong, Marie Ebob Agbortabot
Cameroon, Buea
University of Buea
Mpoudi-Ngole, Emmanuel
Cameroon, Yaounde
Johns Hopkins Cameroon Program
Djoko, Cyrille Finyom
Cameroon, Yaounde
Johns Hopkins Cameroon Program
Tamoufé, Ubald
Cameroon, Yaounde
Johns Hopkins Cameroon Program
Prosser, Adria Tassy
United States, Baltimore
Johns Hopkins Bloomberg School of Public Health
Burke, Donald S.
United States, Pittsburgh
University of Pittsburgh Graduate School of Public Health
Wolfe, Nathan D.
United States, San Francisco
Global Viral Forecasting Initiative
United States, Palo Alto
Stanford University
Statistics
Citations: 28
Authors: 12
Affiliations: 7
Identifiers
Doi:
10.4269/ajtmh.2011.10-0191
ISSN:
00029637
Research Areas
Health System And Policy
Study Design
Cross Sectional Study
Study Approach
Quantitative
Study Locations
Cameroon