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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
medicine
Cardiotoxicity Associated with High-Dose Cyclophosphamide Therapy
Archives of Internal Medicine, Volume 141, No. 6, Year 1981
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Description
The cardiac effects of chemotherapeutic regimens using high doses of cyclophosphamide (180 mg/kg over four days) were assessed in 32 patients with hematologic malignant neoplasms. Left ventricular systolic function, determined by the fractional shortening on echocardiogram, declined substantially five to 16 days after the initiation of cyclophosphamide therapy. Although pericardial effusion on echocardiogram occurred in 33% of the patients studied, ECG voltage decreased five to 14 days after beginning cyclophosphamide therapy even in those patients without pericardial effusion. Congestive heart failure was noted in nine patients (28%) within three weeks of cyclophosphamide administration. Six of these patients (19%) died of myocardial failure. Pericardial tamponade occurred in six patients (19%), including five who died of myocardial failure. Histopathologic and electron microscopic findings showed endothelial injury and a hemorrhagic myopericarditis. Cyclophosphamide in this high dose is associated with a toxic, often fatal, pericardiomyopathy. Depression of ECG voltage and systolic left ventricular function, though common, do not necessarily predict clinical cardiac deterioration. © 1981, American Medical Association. All rights reserved.
Authors & Co-Authors
Gottdiener, John S.
United States, Bethesda
National Institutes of Health Nih
Appelbaum, Frederick R.
United States, Bethesda
National Institutes of Health Nih
Ziegler, John L.
United States, Bethesda
National Institutes of Health Nih
Statistics
Citations: 394
Authors: 3
Affiliations: 1
Identifiers
Doi:
10.1001/archinte.1981.00340060066015
ISSN:
00039926
Research Areas
Cancer
Environmental
Mental Health
Noncommunicable Diseases
Violence And Injury