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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
biochemistry, genetics and molecular biology
Development of a Stress-Inducible Controlled Expression (SICE) system in Lactococcus lactis for the production and delivery of therapeutic molecules at mucosal surfaces
Journal of Biotechnology, Volume 168, No. 2, Year 2013
Notification
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Description
In recent years, recombinant lactic acid bacteria (LAB) have been successfully used as safe mucosal delivery vectors. Herein, we report on the development of a Stress Inducible Controlled Expression (SICE) system in L. lactis for the production and delivery of proteins of health interest (both therapeutic and vaccine related) at mucosal surfaces. This system is episomal in nature and is composed of a vector carrying an expression cassette under the transcriptional control of a stress-inducible promoter. The functionality of the SICE system was validated in vivo using two different routes of administration: oral and intranasal, and in two different murine models of human pathologies: (i) a model of therapy against inflammatory bowel diseases (IBD) and (ii) a model of vaccination against human papillomavirus type-16 (HPV-16). © 2013 Elsevier B.V.
Authors & Co-Authors
Benbouziane, Bouasria
France, Jouy-en-josas
Microbiologie de L'alimentation au Service de la Santé Humaine
Algeria, Mostaganem
Université Abdelhamid Ibn Badis Mostaganem
Ribelles, Pedro
France, Jouy-en-josas
Microbiologie de L'alimentation au Service de la Santé Humaine
Aubry, Camille
France, Jouy-en-josas
Microbiologie de L'alimentation au Service de la Santé Humaine
Martin, Rebeca
France, Jouy-en-josas
Microbiologie de L'alimentation au Service de la Santé Humaine
Kharrat, Pascale
France, Jouy-en-josas
Microbiologie de L'alimentation au Service de la Santé Humaine
Riazi, Ali
Algeria, Mostaganem
Université Abdelhamid Ibn Badis Mostaganem
Langella, Philippe
France, Jouy-en-josas
Microbiologie de L'alimentation au Service de la Santé Humaine
Bermúdez-Humarán, Luis Gilberto
France, Jouy-en-josas
Microbiologie de L'alimentation au Service de la Santé Humaine
Statistics
Citations: 89
Authors: 8
Affiliations: 2
Identifiers
Doi:
10.1016/j.jbiotec.2013.04.019
ISSN:
01681656
e-ISSN:
18734863
Research Areas
Cancer
Health System And Policy