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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
biochemistry, genetics and molecular biology
Database for exploration of functional context of genes implicated in ovarian cancer
Nucleic Acids Research, Volume 37, No. SUPPL. 1, Year 2009
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Description
Ovarian cancer (OC) is becoming the most common gynecological cancer in developed countries and the most lethal gynecological malignancy. It is also the fifth leading cause of all cancer-related deaths in women. The identification of diagnostic biomarkers and development of early detection techniques for OC largely depends on the understanding of the complex functionality and regulation of genes involved in this disease. Unfortunately, information about these OC genes is scattered throughout the literature and various databases making extraction of relevant functional information a complex task. To reduce this problem, we have developed a database dedicated to OC genes to support exploration of functional characterization and analysis of biological processes related to OC. The database contains general information about OC genes, enriched with the results of transcription regulation sequence analysis and with relevant text mining to provide insights into associations of the OC genes with other genes, metabolites, pathways and nuclear proteins. Overall, it enables exploration of relevant information for OC genes from multiple angles, making it a unique resource for OC and will serve as a useful complement to the existing public resources for those interested in OC genetics. Access is free for academic and non-profit users and database can be accessed at http://apps.sanbi.ac.za/ddoc/. © 2008 The Author(s).
Authors & Co-Authors
Kaur, Mandeep
South Africa, Bellville
University of the Western Cape
Radovanovic, Aleksandar
South Africa, Bellville
University of the Western Cape
Essack, Magbubah M.
South Africa, Bellville
University of the Western Cape
Schaefer, Ulf
South Africa, Bellville
University of the Western Cape
Maqungo, Monique
South Africa, Bellville
University of the Western Cape
Kibler, Tracey
South Africa, Bellville
University of the Western Cape
Schmeier, Sebastian
South Africa, Bellville
University of the Western Cape
Christoffels, Alan G.
Singapore, Singapore City
National University Health System
Narasimhan, Kothandaraman
Singapore, Singapore City
National University Health System
Choolani, Mahesh A.
Singapore, Singapore City
National University Health System
Bajic, Vladimir B.
South Africa, Bellville
University of the Western Cape
Statistics
Citations: 11
Authors: 11
Affiliations: 2
Identifiers
Doi:
10.1093/nar/gkn593
ISSN:
03051048
e-ISSN:
13624962
Research Areas
Cancer
Environmental
Genetics And Genomics
Health System And Policy
Participants Gender
Female