Skip to content
Home
About Us
Resources
Profiles Metrics
Authors Directory
Institutions Directory
Top Authors
Top Institutions
Top Sponsors
AI Digest
Contact Us
Menu
Home
About Us
Resources
Profiles Metrics
Authors Directory
Institutions Directory
Top Authors
Top Institutions
Top Sponsors
AI Digest
Contact Us
Home
About Us
Resources
Profiles Metrics
Authors Directory
Institutions Directory
Top Authors
Top Institutions
Top Sponsors
AI Digest
Contact Us
Menu
Home
About Us
Resources
Profiles Metrics
Authors Directory
Institutions Directory
Top Authors
Top Institutions
Top Sponsors
AI Digest
Contact Us
Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
medicine
Analysis of false positive HIV-1 serologic testing in Kenya
Diagnostic Microbiology and Infectious Disease, Volume 9, No. 3, Year 1988
Notification
URL copied to clipboard!
Description
Sera of 95 mothers and 129 children from Nairobi, Kenya, collected in 1976, and of 466 adults and 193 children of Embu District, Kenya, collected in 1984 and 1985, were analyzed for the presence of human immunodeficiency virus type 1 (HIV-1) antibodies. Although no HIV-1 seropositivity was demonstrated by western blot analysis in both study groups, 7% of Nairobi mothers and 10% of adult females from Embu District had false positive results by enzyme immunoassay (EIA) compared with <1% seroreactivity rates observed in adult males and children. False positive results were not due to simian T lymphotropic virus type III (STLV-IIIAGM)/human T lymphotropic virus type IV (HTLV-IV) seropositivity. Sixty-one percent of the HIV-1 EIA reactive sera could not be explained by cytotoxic activity to lymphocytes bearing the HLA-DR4 or HLA-DQw3 phenotype. We conclude that false positive HIV EIA tests are frequently encountered in East Africa. Seroprevalence rates in rural Africa must be interpreted with caution due to the decreased specificity of HIV EIAs. © 1987.
Authors & Co-Authors
Cherry, James D.
Unknown Affiliation
Neumann, Charlotte G.
Unknown Affiliation
Stiehm, Ewald Richard
Unknown Affiliation
Ettenger, Robert Bruce
Unknown Affiliation
Bwibo, Nimrod O.
Unknown Affiliation
Koech, David Kiprotich
Unknown Affiliation
Statistics
Citations: 2
Authors: 6
Identifiers
Doi:
10.1016/0732-8893(88)90027-2
ISSN:
07328893
Research Areas
Infectious Diseases
Maternal And Child Health
Study Locations
Multi-countries
Kenya
Participants Gender
Female