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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
Population pharmacokinetics of lumefantrine in pregnant and nonpregnant women with uncomplicated plasmodium falciparum malaria in Uganda
CPT: Pharmacometrics and Systems Pharmacology, Volume 2, No. 11, Article e83, Year 2013
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Description
Pregnancy alters the pharmacokinetic properties of many antimalarial compounds. The objective of this study was to evaluate the pharmacokinetic properties of lumefantrine in pregnant and nonpregnant women with uncomplicated Plasmodium falciparum malaria in Uganda after a standard fixed oral artemether-lumefantrine treatment. Dense venous (n = 26) and sparse capillary (n = 90) lumefantrine samples were drawn from pregnant patients. A total of 17 nonpregnant women contributed with dense venous lumefantrine samples. Lumefantrine pharmacokinetics was best described by a flexible absorption model with multiphasic disposition. Pregnancy and body temperature had a significant impact on the pharmacokinetic properties of lumefantrine. Simulations from the final model indicated 27% lower day 7 concentrations in pregnant women compared with nonpregnant women and a decreased median time of 0.92 and 0.42 days above previously defined critical concentration cutoff values (280 and 175 ng/ml, respectively). The standard artemether-lumefantrine dose regimen in P. falciparum malaria may need reevaluation in nonimmune pregnant women. © 2013 ASCPT.
Available Materials
https://efashare.b-cdn.net/share/pmc/articles/PMC3852159/bin/psp201359x1.zip
Authors & Co-Authors
Kloprogge, Frank
Thailand, Nakhon Pathom
Mahidol University
United Kingdom, Oxford
University of Oxford
Piola, Patrice
United Kingdom, Oxford
University of Oxford
France, Paris
Epicentre
Uganda, Mbarara
Mbarara University of Science and Technology
Dhorda, M. J.
France, Paris
Epicentre
United States, Baltimore
University of Maryland School of Medicine
Muwanga, Sulaiman
France, Paris
Epicentre
Turyakira, Eleanor
Uganda, Mbarara
Mbarara University of Science and Technology
France, Paris
Epicentre
Apinan, S.
Thailand, Nakhon Pathom
Mahidol University
Lindegårdh, Niklas
Thailand, Nakhon Pathom
Mahidol University
United Kingdom, Oxford
University of Oxford
Nosten, François Henry
Thailand, Nakhon Pathom
Mahidol University
United Kingdom, Oxford
University of Oxford
Thailand, Mae Sod
Shoklo Malaria Research Unit
Day, Nichloas P.J.
Thailand, Nakhon Pathom
Mahidol University
United Kingdom, Oxford
University of Oxford
White, Nicholas J.
Thailand, Nakhon Pathom
Mahidol University
United Kingdom, Oxford
University of Oxford
Guérin, Philippe Jean Jean
United Kingdom, Oxford
University of Oxford
France, Paris
Epicentre
Tarning, Joel
Thailand, Nakhon Pathom
Mahidol University
United Kingdom, Oxford
University of Oxford
Statistics
Citations: 49
Authors: 12
Affiliations: 6
Identifiers
Doi:
10.1038/psp.2013.59
e-ISSN:
21638306
Research Areas
Health System And Policy
Infectious Diseases
Maternal And Child Health
Sexual And Reproductive Health
Study Design
Cross Sectional Study
Study Locations
Uganda
Participants Gender
Female