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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
pharmacology, toxicology and pharmaceutics
Evaluation of five medicinal plants used in diarrhoea treatment in Nigeria
Journal of Ethnopharmacology, Volume 101, No. 1-3, Year 2005
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Description
Five medicinal plants [Acacia nilotica, Acanthospermun hispidum, Gmelina arborea, Parkia biglobosa and Vitex doniana] used in diarrhoeal treatment in Kaduna State, Nigeria, were investigated. This study was carried out on perfused isolated rabbit jejunum and castor oil-induced diarrhoea in mice. The aqueous methanol extracts (0.5, 1.0, 2.0 and 3.0 mg/ml) were generally found to cause a dose-dependent response in the isolated rabbit jejunum, though this was not uniform in all the plants. Gmelina arborea and Vitex doniana showed concentration dependent relaxation at low doses (0.5, 1.0 mg/ml), but showed no significant relaxation at higher doses (2.0, 3.0 mg/ml). Other extracts showed biphasic effects. For example, Acacia nilotica at 3.0 mg/ml caused initial relaxation quickly followed by contraction. In the castor oil-induced diarrhoeal, 100% protections were shown by extracts of Acacia nilotica and Parkia biglobosa (100, 200 mg/kg) while Vitex doniana showed a dose-dependent effect. The least protection was shown by Acanthospermun hispidum, at the same dose, when compared with the other four plants. The results obtained revealed that the aqueous methanol extracts of all the five medicinal plants investigated have pharmacological activity against diarrhoea. This may explain their use in traditional medicine for the treatment of diarrhoea. © 2005 Elsevier Ireland Ltd. All rights reserved.
Authors & Co-Authors
Agunu, Abdulkarim
Nigeria, Zaria
Ahmadu Bello University
Yusuf, Sadiq A.
Nigeria, Zaria
Ahmadu Bello University
Andrew, G. O.
Nigeria, Zaria
Ahmadu Bello University
Zezi, Abdulkadir Umar
Nigeria, Zaria
Ahmadu Bello University
Abdurahman, Ezzeldin Mukhtar
Nigeria, Zaria
Ahmadu Bello University
Statistics
Citations: 214
Authors: 5
Affiliations: 1
Identifiers
Doi:
10.1016/j.jep.2005.03.025
ISSN:
03788741
Research Areas
Health System And Policy
Infectious Diseases
Study Locations
Nigeria