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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
biochemistry, genetics and molecular biology
The effect of introduction of universal childhood hepatitis B immunization in South Africa on the prevalence of serologically negative hepatitis B virus infection and the selection of immune escape variants
Vaccine, Volume 19, No. 28-29, Year 2001
Notification
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Description
The effect of universal hepatitis B vaccination on the prevalence of serologically negative hepatitis B virus infection (HBV) and the emergence of HBsAg variants is unknown. We prospectively studied two different cohorts of 12-24 month old children in South Africa. They consisted of the unvaccinated children (n = 459) born before the introduction of universal vaccination and the vaccinated children (n = 1213) between 1 and 2 years after the introduction of the vaccination program. The frequency of detecting HBV DNA by PCR was reduced from 6.5% in unvaccinated children to 0.3% in vaccinated children (P < 0.00001). There were no unique amino acid substitutions within the major hydrophilic region of the S sequence in both pre- and post-vaccination samples. Universal childhood vaccination reduced the frequency of serologically negative HBV infection and did not necessarily lead to selection of escape variants. © 2001 Elsevier Science Ltd.
Authors & Co-Authors
Hino, Keisuke
Japan, Ube
Yamaguchi University School of Medicine
United Kingdom, Glasgow
University of Glasgow
Katoh, Yoshiharu
Japan, Ube
Yamaguchi University School of Medicine
Vardas, Eftyhia
South Africa, Johannesburg
University of the Witwatersrand
Sim, John G.M.
South Africa, Johannesburg
University of the Witwatersrand
Okita, Kiwamu
Japan, Ube
Yamaguchi University School of Medicine
Carman, William F.
United Kingdom, Glasgow
University of Glasgow
Statistics
Citations: 41
Authors: 6
Affiliations: 3
Identifiers
Doi:
10.1016/S0264-410X(01)00121-9
ISSN:
0264410X
Research Areas
Genetics And Genomics
Infectious Diseases
Maternal And Child Health
Study Design
Cross Sectional Study
Cohort Study
Study Locations
South Africa