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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
agricultural and biological sciences
Histopathological studies in two strains of semi-immune mice infected with Plasmodium berghei ANKA after chronic exposure
Parasitology Research, Volume 108, No. 4, Year 2011
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Description
To mimic a human malaria infection in the endemic condition, two strains of mice (Balb/c and CBA) were infected and treated several times to generate so-called semi-immune status. As previously reported, neither mice (Balb/c and CBA) strain showed cerebral malaria, even in the susceptible C57BL/6 (B6). The significant difference between the mice strains in our previous study was the rate of destruction of uninfected red blood cells (uRBCs) at infection. After the established repeated cycles of infection and treatment and the final challenge with 104 Plasmodium berghei ANKA until minimum Hb, Balb/c and CBA mice were sacrificed. The spleen, liver, brain, kidney, lung, heart, and muscle were removed, stained with hematoxylin-eosin and analyzed with light microscopy. Previous observation suggested that Balb/c destroyed uRBC at much higher rate than the other strains although the parasitemia was very low. Pathological investigation carried out in this study revealed that this destruction was mainly contributed by the uRBCs as no parasite sequestration was observed in any of the organs. However, malaria pigment deposition was observed in spleen and liver of all the semi-immune mice strains. This histopathological study in the severe malaria anemia model, which is difficult to conduct in humans, will be helpful in taking into account different responses to malaria infection when designing therapeutic interventions and vaccine studies. © Springer-Verlag 2010.
Authors & Co-Authors
Helegbe, Gideon Kofi
Japan, Nagasaki
Nagasaki University
Ghana
Smhs
Yanagi, Tetsuo
Japan, Nagasaki
Nagasaki University
Senba, Masachika
Japan, Nagasaki
Nagasaki University
Huy, Nguyen Tien
Japan, Nagasaki
Nagasaki University
Shuaibu, Mohammed Nasir
Japan, Nagasaki
Nagasaki University
Yamazaki, Akiko
Japan, Nagasaki
Nagasaki University
Kikuchi, Mihoko
Japan, Nagasaki
Nagasaki University
Yasunami, Michio
Japan, Nagasaki
Nagasaki University
Hirayama, Kenji
Japan, Nagasaki
Nagasaki University
Statistics
Citations: 24
Authors: 9
Affiliations: 2
Identifiers
Doi:
10.1007/s00436-010-2121-6
ISSN:
09320113
e-ISSN:
14321955
Research Areas
Infectious Diseases