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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
immunology and microbiology
In vitro resistance patterns of Plasmodium falciparum to chloroquine—a reflection of strain-specific immunity
Transactions of the Royal Society of Tropical Medicine and Hygiene, Volume 84, No. 5, Year 1990
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Description
Studies in vitro among children on the response of Plasmodium falciparum to chloroquine were conducted as part of the national long-term monitoring of drug resistance in a holo- to hyperendemic malarious area of Tanzania between 1983 and 1989. Overall, no significant increase in chloroquine resistance was observed. However, in children under 5 years old resistance increased during this period, whereas in schoolchildren resistance decreased from 1986 to 1989. A hypothesis based on antigenic differences between resistant and sensitive strains is proposed to explain this age-specific pattern. If immunity develops principally against the most frequent parasite strains, then as it develops the numbers of the most frequent strains will be reduced, whilst the rare strains may become predominant and thus be detected in the blood of immune patients. Thus, in an endemic area, the observed resistance pattern in non-immune infants will differ from that in immune schoolchildren, as was observed in the present study. These findings may have important implications for the control of malaria and the development of vaccines. © 1990 Oxford University Press. All Rights Reserved.
Authors & Co-Authors
Koella, Jacob C.
Switzerland, Allschwil
Swiss Tropical and Public Health Institute Swiss Tph
Hatz, Christoph F.R.
Tanzania
Swiss Tropical Field Laboratory
Mshinda, Hassan M.
Tanzania
Swiss Tropical Field Laboratory
de Savigny, Don H.
Tanzania
Swiss Tropical Field Laboratory
MacPherson, Calum N.L.
Tanzania
Swiss Tropical Field Laboratory
Degrémont, Antoine A.
Switzerland, Allschwil
Swiss Tropical and Public Health Institute Swiss Tph
Tanner, Marcel
Switzerland, Allschwil
Swiss Tropical and Public Health Institute Swiss Tph
Statistics
Citations: 19
Authors: 7
Affiliations: 2
Identifiers
Doi:
10.1016/0035-9203(90)90135-2
ISSN:
00359203
e-ISSN:
18783503
Research Areas
Infectious Diseases
Maternal And Child Health
Study Locations
Tanzania