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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
general
Variants in the SP110 gene are associated with genetic susceptibility to tuberculosis in West Africa
Proceedings of the National Academy of Sciences of the United States of America, Volume 103, No. 27, Year 2006
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Description
The ssti locus has been identified in a mouse model to control resistance and susceptibility of Mycobacterium tuberculosis infection. Subsequent studies have now identified Ipr1 (intracellular pathogen resistance 1) to be the gene responsible. Ipr1 is encoded within the ssti locus and is expressed in the tuberculosis lung lesions and macrophages of sst1-resistant, but not sst1-susceptible mice. We have therefore examined the closest human homologue of Ipr1, SP110, for its ability to control susceptibility to M. tuberculosis infection in humans. In a study of families from The Gambia we have identified three polymorphisms that are associated with disease. On examination of additional families from Guinea-Bissau and the Republic of Guinea, two of these associations were independently replicated. These variants are in strong linkage disequilibrium with each other and lie within a 31-kb block of low haplotypic diversity, suggesting that a polymorphism within this region has a role in genetic susceptibility to tuberculosis in humans. © 2006 by The National Academy of Sciences of the USA.
Available Materials
https://efashare.b-cdn.net/share/pmc/articles/PMC1502463/bin/pnas_0603340103_index.html
https://efashare.b-cdn.net/share/pmc/articles/PMC1502463/bin/pnas_0603340103_1.pdf
Authors & Co-Authors
Tosh, Kerrie
Unknown Affiliation
Campbell, Sarah J.
Unknown Affiliation
Fielding, Katherine Linda
Unknown Affiliation
Sillah, Jackson S.
Unknown Affiliation
Bah, Boubacar Sidy Sily
Unknown Affiliation
Gustafson, Per
Unknown Affiliation
Manneh, Kebba
Unknown Affiliation
Lisse, Ida Maria
Unknown Affiliation
Sirugo, G.
Unknown Affiliation
Bennett, Steve
Unknown Affiliation
Aaby, Peter
Unknown Affiliation
McAdam, Keith P.W.J.
Unknown Affiliation
Bah Sow, Oumou
Unknown Affiliation
Lienhardt, Christian
Unknown Affiliation
Kramnik, Igor B.
Unknown Affiliation
Hill, Adrian V. S.
Unknown Affiliation
Statistics
Citations: 119
Authors: 16
Affiliations: 9
Identifiers
Doi:
10.1073/pnas.0603340103
ISSN:
00278424
Research Areas
Genetics And Genomics
Study Locations
Multi-countries
Gambia
Guinea
Guinea-Bissau