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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
medicine
Drug-resistant ventilator associated pneumonia in a tertiary care hospital in Saudi Arabia
Annals of Thoracic Medicine, Volume 9, No. 2, Year 2014
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Description
Background: There is a wide geographic and temporal variability of bacterial resistance among microbial causes of ventilator-associated pneumonia (VAP). The contribution of multi-drug resistant (MDR) pathogens to the VAP etiology in Saudi Arabia was never studied. We sought to examine the extent of multiple-drug resistance among common microbial causes of VAP. Materials and Methods: We conducted a retrospective susceptibility study in the adult intensive care unit (ICU) of King Abdulaziz Medical City, Riyadh, Saudi Arabia. Susceptibility results of isolates from patients diagnosed with VAP between October 2004 and June 2009 were examined. The US National Healthcare Safety Network definition of MDR was adopted. Results: A total of 248 isolates including 9 different pathogens were included. Acinetobacter spp. was highly (60-89%) resistant to all tested antimicrobials, including carbapenems (three- and four-class MDR prevalence were 86% and 69%, respectively). Pseudomonas aeruginosa was moderately (13-31%) resistant to all tested antimicrobials, including antipseudomonal penicillins (three- and four-class MDR prevalence were 13% and 10%, respectively). With an exception of ampicillin (fully resistant), Klebsiella spp. had low (0-13%) resistance to other tested antimicrobials with no detected MDR. Staphylococcus aureus was fully susceptible to vancomycin with 42% resistance to oxacillin. There were significant increasing trends of MDR Acinetobacter spp. however not P. aeruginosa during the study. Resistant pathogens were associated with worse profile of ICU patients but not patients′ outcomes. Conclusion: Acinetobacter in the current study was an increasingly resistant VAP-associated pathogen more than seen in many parts of the world. The current finding may impact local choice of initial empiric antibiotics. Copyright © 2014 by The Saudi Thoracic Society.
Authors & Co-Authors
Balkhy, Hanan H.
Saudi Arabia, Riyadh
King Abdulaziz Medical City - Riyadh
Saudi Arabia, Riyadh
Who Collaborating Center for Infection Prevention and Control
Saudi Arabia, Riyadh
King Saud Bin Abdulaziz University for Health Sciences
El-Saed, Aiman
Saudi Arabia, Riyadh
King Abdulaziz Medical City - Riyadh
Saudi Arabia, Riyadh
Who Collaborating Center for Infection Prevention and Control
Saudi Arabia, Riyadh
King Saud Bin Abdulaziz University for Health Sciences
Egypt, Mansoura
Faculty of Medicine
Maghraby, Rana
Saudi Arabia, Riyadh
King Abdulaziz Medical City - Riyadh
Al-Dorzi, Hasan M.
Saudi Arabia, Riyadh
King Saud Bin Abdulaziz University for Health Sciences
Saudi Arabia, Riyadh
King Abdulaziz Medical City - Riyadh
Khan, Raymond
Saudi Arabia, Riyadh
King Abdulaziz Medical City - Riyadh
Rishu, Asgar H.
Saudi Arabia, Riyadh
King Abdulaziz Medical City - Riyadh
Arabi, Yaseen M.
Saudi Arabia, Riyadh
King Saud Bin Abdulaziz University for Health Sciences
Saudi Arabia, Riyadh
King Abdulaziz Medical City - Riyadh
Statistics
Citations: 25
Authors: 7
Affiliations: 4
Identifiers
Doi:
10.4103/1817-1737.128858
ISSN:
18171737
e-ISSN:
19983557
Research Areas
Health System And Policy
Study Design
Cross Sectional Study
Cohort Study