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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
medicine
Alirocumab and cardiovascular outcomes after acute coronary syndrome
New England Journal of Medicine, Volume 379, No. 22, Year 2018
Notification
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Description
BACKGROUND Patients who have had an acute coronary syndrome are at high risk for recurrent ischemic cardiovascular events. We sought to determine whether alirocumab, a human monoclonal antibody to proprotein convertase subtilisin-kexin type 9 (PCSK9), would improve cardiovascular outcomes after an acute coronary syndrome in patients receiving high-intensity statin therapy. METHODS We conducted a multicenter, randomized, double-blind, placebo-controlled trial involving 18,924 patients who had an acute coronary syndrome 1 to 12 months earlier, had a low-density lipoprotein (LDL) cholesterol level of at least 70 mg per deciliter (1.8 mmol per liter), a non-highdensity lipoprotein cholesterol level of at least 100 mg per deciliter (2.6 mmol per liter), or an apolipoprotein B level of at least 80 mg per deciliter, and were receiving statin therapy at a high-intensity dose or at the maximum tolerated dose. Patients were randomly assigned to receive alirocumab subcutaneously at a dose of 75 mg (9462 patients) or matching placebo (9462 patients) every 2 weeks. The dose of alirocumab was adjusted under blinded conditions to target an LDL cholesterol level of 25 to 50 mg per deciliter (0.6 to 1.3 mmol per liter). The primary end point was a composite of death from coronary heart disease, nonfatal myocardial infarction, fatal or nonfatal ischemic stroke, or unstable angina requiring hospitalization. RESULTS The median duration of follow-up was 2.8 years. A composite primary end-point event occurred in 903 patients (9.5%) in the alirocumab group and in 1052 patients (11.1%) in the placebo group (hazard ratio, 0.85; 95% confidence interval [CI], 0.78 to 0.93; P<0.001). A total of 334 patients (3.5%) in the alirocumab group and 392 patients (4.1%) in the placebo group died (hazard ratio, 0.85; 95% CI, 0.73 to 0.98). The absolute benefit of alirocumab with respect to the composite primary end point was greater among patients who had a baseline LDL cholesterol level of 100 mg or more per deciliter than among patients who had a lower baseline level. The incidence of adverse events was similar in the two groups, with the exception of local injection-site reactions (3.8% in the alirocumab group vs. 2.1% in the placebo group). CONCLUSIONS Among patients who had a previous acute coronary syndrome and who were receiving highintensity statin therapy, the risk of recurrent ischemic cardiovascular events was lower among those who received alirocumab than among those who received placebo. © 2018 Massachusetts Medical Society.
Authors & Co-Authors
Schwartz, Gregory G.
United States, Aurora
University of Colorado Anschutz Medical Campus
Canada, Edmonton
University of Alberta
Canada, Toronto
University of Toronto
Steg, Philippe Gabriel
France, Paris
Ap-hp Assistance Publique - Hopitaux de Paris
United Kingdom, London
Imperial College London
France, Paris
Hôpital Bichat-claude-bernard Ap-hp
Szarek, Michael J.
United States, Albany
State University of new York System
Bhatt, Deepak L.
United States, Boston
Brigham and Women's Hospital
Bittner, Vera A.
United States, Birmingham
The University of Alabama at Birmingham
Díaz, Rafaël J.
Argentina, Rosario
Etudios Cardiologica Latin America, Rosario
Edelberg, Jay M.
France, Gentilly
Sanofi S.a.
Goodman, Shaun G.
Canada, Edmonton
University of Alberta
Canada, Toronto
University of Toronto
Hanotin, Corinne
France, Gentilly
Sanofi S.a.
Harrington, Robert A.
United States, Palo Alto
Stanford University
United States, Durham
Duke University
Jukema, Johan Wouter
Netherlands, Leiden
Leids Universitair Medisch Centrum
Lecorps, Guillaume
France, Gentilly
Sanofi S.a.
Mahaffey, Kenneth W.
United States, Palo Alto
Stanford University
United States, Chapel Hill
The University of North Carolina at Chapel Hill
Moryusef, Angèle
France, Gentilly
Sanofi S.a.
Pordy, Robert
United States, Tarrytown
Regeneron Pharmaceuticals, Inc.
Quintero, Kirby
United States, Durham
Duke University Medical Center
Roe, Matthew T.
United States, Durham
Duke University Medical Center
United States, Durham
Duke University School of Medicine
United States, Durham
Duke Clinical Research Institute
United States, Durham
Duke University
Sasiela, William J.
United States, Tarrytown
Regeneron Pharmaceuticals, Inc.
Tamby, Jean François
France, Gentilly
Sanofi S.a.
Tricoci, Pierluigi
United States, Durham
Duke University Medical Center
United States, Durham
Duke University
White, Harvey D.
New Zealand, Auckland
Auckland City Hospital
Zeiher, Andreas Michael
Germany, Frankfurt am Main
Goethe-universität Frankfurt am Main
Aylward, Philip E.G.
Australia, Adelaide
South Australian Health and Medical Research Institute
Drexel, Heinz
Austria, Feldkirch
Landeskrankenhaus Feldkirch
Austria, Feldkirch
Vorarlberg Inst Vaskulare Forsch Vivit
Sinnaeve, Peter R.
Belgium, Leuven
Ku Leuven– University Hospital Leuven
Dilić, Mirza
Bosnia and Herzegovina, Sarajevo
Klinicki Centar Univerziteta u Sarajevu
Lópes, Renato Deláscio
United States, Durham
Duke University Medical Center
United States, Durham
Duke University
Brazil, Sao Paulo
Universidade Federal de São Paulo
Gotcheva, Nina N.
Bulgaria, Sofia
Mhat National Cardiology Hospital Ead
Prieto, Juan Carlos D.
Chile, Santiago
Hospital Clínico Universidad de Chile
Yong, Huo
China, Beijing
Peking University First Hospital
López-Jaramillo, P.
Colombia, Floridablanca
Fdn Oftalmol Santander Foscal
Pečin, Ivan
Croatia, Zagreb
University of Zagreb
Reiner, Željko
Croatia, Zagreb
University of Zagreb
Ošťǎdal, Petr
Czech Republic, Prague
Na Homolce Hospital
Czech Republic, Prague
Nemocnice na Homolce
Poulsen, Steen Hvitfeldt
Denmark, Aarhus
Aarhus Universitetshospital
Viigimaa, Margus
Estonia, Tallinn
Sa Pohja Eesti Reg Haigla
Nieminen, Markku Sakari
Finland, Helsinki
Helsinki University Hospital
Danchin, Nicolas
France, Paris
Hôpital Européen Georges-pompidou
Chumburidze, Vakhtang
Georgia, Tbilisi
Chapidze Emergency Cardiology Center
Marx, Nikolaus
Germany, Aachen
Uniklinik Rwth Aachen
Liberopoulos, Evangelos N.
Greece, Ioannina
University General Hospital of Ioannina
Valdovinos, Pablo Carlos Montenegro
Guatemala, Guatemala City
Unidad Diagnost Cardiol
Tse, Hung Fat
Hong Kong
Queen Mary Hospital Hong Kong
Kiss, Róbert Gábor
Hungary, Budapest
Magyar Honvédség Egészségügyi Központ
Xavier, Denis
India, Bengaluru
St. John's Medical College
Zahger, Doron
Israel, Beer Sheva
Soroka University Medical Center
Valgimigli, Marco
Italy, Ferrara
University of Ferrara
Kimura, Takeshi
Japan, Kyoto
Kyoto University
Japan, Kyoto
Kyoto University Hospital
Kim, Hyosoo
South Korea, Seoul
Seoul National University Hospital
Kim, Sanghyun
South Korea, Seoul
Seoul Metropolitan Government - Seoul National University Borame Medical Center
Erglis, Andrejs
Latvia, Riga
Paula Stradina Clinical University Hospital
LauceviÄius, Aleksandras
Lithuania, Vilnius
Vilniaus Universitetas
Kedev, Saško A.
North Macedonia, Skopje
University Clinic of Cardiology
Yusoff, Khalid
Malaysia, Batu Caves
University Technology Mara Uitm
Malaysia, Kuala Lumpur
Ucsi University
Ramos López, Gabriel Arturo
Mexico, Guadalajara, Jalisco
Med Off
Alings, Marco A.
Netherlands, Breda
Amphia Hospital
Halvorsen, Sigrun
Norway, Oslo
Universitetet I Oslo
Correa Flores, Roger Martin
Peru, Bellavista
Hospital Nacional Alberto Sabogal Sologuren, Essalud
Sy, Rody G.
Philippines, San Juan
Cardinal Santos Medical Center
Budaj, Andrzej J.
Poland, Warsaw
Szpital Grochowski, Warszawa
Morais, João Carlos Araujo
Portugal, Leiria
Leiria Hospital Centre
Dorobanţu, Maria I.
Romania, Bucharest
Bucharest Clinical Emergency Hospital
Karpov, Yu Aleksandrovich
Russian Federation, Moscow
National Medical Research Center of Cardiology of the Ministry of Healthcare of the Russian Federation
Ristić, Arsen D.
Serbia, Belgrade
Klinicki Centar Srbije
Chua, Terrance S.J.
Singapore, Singapore City
National Heart Centre Singapore
Murín, Ján
Slovakia, Bratislava
Univ Nemocn Bratislava
Fras, Zlatko
Slovenia, Ljubljana
Univerzitetni Klinični Center Ljubljana
Slovenia, Ljubljana
Univerza V Ljubljani
Dalby, Anthony John
South Africa, Johannesburg
Milpark Hospital
Tuñón, José
Spain, Madrid
Fdn Jimenez Diaz Hosp. Bibliovirtual
de Silva, Hithanadura Asita
Sri Lanka, Kelaniya
University of Kelaniya
Hagström, Emil G.
Sweden, Uppsala
Akademiska Sjukhuset
Müller, Christian E.
Switzerland, Basel
Universitätsspital Basel
Chiang, Chernen
Taiwan, Taipei
Taipei Veterans General Hospital
Taiwan, Taipei
National Yang-ming University Taiwan
Sritara, Piyamitr
Thailand, Bangkok
Ramathibodi Hospital
Güneri, Sema
Turkey, Izmir
Dokuz Eylül Üniversitesi
Ray, Kausik K.
United Kingdom, London
Imperial College London
Moriarty, Patrick Maurice
United States, Kansas City
University of Missouri-kansas City
Vogel, Robert A.
United States, Denver
University of Colorado Denver
Chaitman, Bernard R.
United States, St. Louis
Saint Louis University
Kelsey, Sheryl F.
United States, Pittsburgh
University of Pittsburgh
Olsson, Anders G.
Sweden, Linkoping
Linköpings Universitet
Rouleau, Jean-Lucien Lucien
Canada, Montreal
University of Montreal
Simoons, Maarten L.
Netherlands, Rotterdam
Erasmus Mc
Alexander, Karen P.
United States, Durham
Duke University
Meloni, Chiara
United States, Durham
Duke University Medical Center
Rosenson, Robert Sidney
United States, New York
Icahn School of Medicine at Mount Sinai
Sijbrands, Eric J.G.
Netherlands, Rotterdam
Erasmus Mc
Alexander, John Hunter P.
United States, Durham
Duke University
Armaganijan, Luciana Vidal
Brazil, Sao Paulo
Brazilian Clinical Research Institute
Bagai, Akshay
Canada, Toronto
University of Toronto
Bahit, María Cecilia
Brazil, Sao Paulo
Brazilian Clinical Research Institute
Brennan, James Matthew
United States, Durham
Duke University
Clifton, Shaun
United States, Durham
Duke University
DeVore, Adam D.
United States, Durham
Duke University
Deloatch, Shalonda
United States, Durham
Duke University
Dickey, Sheila
United States, Durham
Duke University
Dombrowski, Keith E.
United States, Durham
Duke University
Ducrocq, Grégory
France, Paris
Ap-hp Assistance Publique - Hopitaux de Paris
Eapen, Zubin J.
United States, Durham
Duke University
Hess, Connie Ng
United States, Denver
University of Colorado Denver
Kolls, Brad J.
United States, Durham
Duke University
Leonardi, Sergio
Italy, Pavia
Fondazione Irccs Policlinico San Matteo
Mehta, Rajendra H.
United States, Durham
Duke University
Van-Diepen, Sean F.P.
Canada, Edmonton
University of Alberta
Schiavi, Lilia Beatriz
Unknown Affiliation
Garrido, Marcelo A.
Unknown Affiliation
Bordonava, Anselmo Paulino
Unknown Affiliation
Duronto, Ernesto A.
Unknown Affiliation
Novaretto, Leonardo P.
Unknown Affiliation
Montaña, Oscar R.
Unknown Affiliation
Caccavo, Alberto
Unknown Affiliation
Gomez Vilamajó, Oscar Alberto
Unknown Affiliation
Lorenzatti, Alberto J.
Unknown Affiliation
Cartasegna, Luis Rodolfo
Argentina, Buenos Aires
Instituto Universitario Del Hospital Italiano de Buenos Aires
MacKinnon, Ignacio J.
Unknown Affiliation
Bono, Julio Oscar Emilio
Argentina, Cordoba
Sanatorio Allende
Hrabar, Adrián D.
Unknown Affiliation
Ahuad-Guerrero, Rodolfo Andres
Unknown Affiliation
Zaidman, Cesar Javier
Unknown Affiliation
Dran, Ricardo Dario
Unknown Affiliation
Vico, Marisa Liliana
Unknown Affiliation
Bustamante-Labarta, Miguel H.
Unknown Affiliation
Nani, Sebastián
Unknown Affiliation
Luciardi, Héctor Lucas
Unknown Affiliation
Waisman, Gabriel Darío
Argentina, Buenos Aires
Instituto Universitario Del Hospital Italiano de Buenos Aires
Garcia-Duran, Ruben Omar
Unknown Affiliation
Cestari, Horacio G.
Argentina, Buenos Aires
Sanatorio Guemes
Lúquez, Hugo A.
Unknown Affiliation
Shaw, Jonathan E.
Australia, Melbourne
The Alfred
Horowitz, John D.
Australia, Woodville South
The Queen Elizabeth Hospital, North Western Adelaide Health Service
Colquhoun, David M.
Australia, Brisbane
The Wesley Hospital
Lehman, Sam J.
Unknown Affiliation
Garrahy, Paul John
Australia, Woolloongabba
Princess Alexandra Hospital
Zweiker, Robert
Austria, Graz
Lkh-universitätsklinikum Graz
Hoppe, Uta Charlotte
Unknown Affiliation
Huber, Kurt
Austria, Vienna
Wiener Krankenanstaltenverbund
Weidinger, Franz F.
Austria, Vienna
Rudolfstifung Hospital
Hoffer, Etienne P.
Belgium, Liege
Centre Hospitalier Regional de la Citadelle
Vrolix, Mathias C.M.
Belgium, Genk
Ziekenhuis Oost-limburg
Dujardin, Karl
Belgium, Roeselare
Az Delta
Beauloye, Christophe R.
Unknown Affiliation
Barbato, Emanuele
Belgium, Aalst
Onze Lieve Vrouw Hospital
Claeys, Marc J.
Unknown Affiliation
Cools, Frank Johan C.
Belgium, Brasschaat
Algemeen Ziekenhuis Klina
Terzic´, Ibrahim
Unknown Affiliation
Baraković, Fahir
Unknown Affiliation
Pojskić, Belma
Bosnia and Herzegovina, Zenica
Cantonal Hospital Zenica
Fazlibegović, Emir
Bosnia and Herzegovina, Mostar
University Clinical Hospital Mostar
Durak-Nalbantić, Azra
Bosnia and Herzegovina, Sarajevo
Klinicki Centar Univerziteta u Sarajevu
Vulić, Duško B.
Bosnia and Herzegovina, Banja Luka
Clinical Center Banja Luka
Muslibegovic, Adis
Unknown Affiliation
Reis, Gilmar
Unknown Affiliation
Nicolau, José Carlos
Brazil, Sao Paulo
Universidade de São Paulo
Maia, Lília Nigro
Unknown Affiliation
Rossi, Paulo R.F.
Unknown Affiliation
Kormann, Adrian Paulo Morales
Unknown Affiliation
Abrantes, José Antonio M.
Unknown Affiliation
Botelho, Roberto Vieira
Unknown Affiliation
Précoma, Dalton Bertolim
Unknown Affiliation
Marin-Neto, José Antonio
Brazil, Sao Paulo
Universidade de São Paulo
Ritt, Luiz Eduardo Fonteles
Brazil, Salvador
Hospital Santa Izabel
Reis, Hélder José Lima
Unknown Affiliation
Raev, Dimitar H.
Unknown Affiliation
Stone, James A.
Unknown Affiliation
Gosselin, Gilbert
Unknown Affiliation
Kouz, Simon M.
Canada, Joliette
Centre Hospitalier Régional de Lanaudière
Davies, Richard Y.
Canada, Ottawa
Institut de Cardiologie de L'université D'ottawa
Vijayaraghavan, Ram
Unknown Affiliation
Mehta, Shamir R.
Canada, Hamilton
Hamilton General Hospital
Rodés-Cabau, Josep
Canada, Quebec
Institut Universitaire de Cardiologie et de Pneumologie de Québec - Université Laval
Bata, Iqbal R.
Canada, Halifax
Qeii Health Sciences Centre
Olivares, Claudia
Unknown Affiliation
Chen, Jiyan
China, Guangzhou
Guangdong Provincial People’s Hospital of Southern Medical University
Li, Jianping
Unknown Affiliation
Cheng, Xiaoshu
China, Nanchang
Nanchang University
Chen, Yundai
China, Beijing
General Hospital of People's Liberation Army
Li, Ying
China, Shanghai
Shanghai Dongfang Hospital
Yuan, Zuyi
China, Xi'an
Xi'an Jiaotong University
Ge, Junbo
China, Shanghai
Zhongshan Hospital
de Salazar, Dora Inés Molina
Unknown Affiliation
Mendoza, José Luis Accini
Unknown Affiliation
Urina-Triana, Miguel
Unknown Affiliation
Špinar, Jindřich
Czech Republic, Brno
Fakultni Nemocnice Brno
Linhart, Aleš
Czech Republic, Prague
Všeobecná Fakultní Nemocnice V Praze
Rokyta, Richard
Czech Republic, Pilsen
Fakultní Nemocnice Plzeň
Coufal, Zdeněk
Unknown Affiliation
Adámková, Věra
Unknown Affiliation
Mot'ovská, Zuzana
Czech Republic, Prague
Fakultní Nemocnice Královské Vinohrady
Raungaard, Bent
Unknown Affiliation
Clemmensen, Peter Michael
Denmark, Copenhagen
Rigshospitalet
Bang, Lia Evi
Denmark, Copenhagen
Rigshospitalet
Hove, Jens D.
Denmark, Hvidovre
Hvidovre Hospital
Jeppesen, Jørgen Lykke
Unknown Affiliation
Klausen, Ib Christian
Denmark, Viborg
Regionshospitalet Viborg
Taskinen, Marja Riitta
Finland, Helsinki
Biomedicum Helsinki
Finland, Helsinki
Helsinki University Hospital
Porthan, Kimmo Markus
Finland, Helsinki
Biomedicum Helsinki
Finland, Helsinki
Helsinki University Hospital
Airaksinen, Juhani K.E.
Finland, Turku
Turun Yliopistollinen Keskussairaala
Juonala, Markus T.
Finland, Turku
Turun Yliopistollinen Keskussairaala
Taurio, Jyrki
Finland, Tampere
University Hospital of Tampere
Huikuri, Heikki V.
Finland, Oulu
Oulu University Hospital
Finland, Oulu
Oulun Yliopisto
Coste, Pierre
France, Pessac
Hopital Haut-lévêque C.h.u de Bordeaux
Ferrari, Émile
Unknown Affiliation
Morel, Olivier
France, Strasbourg
Hopital Civil
Montalescot, Gilles
France, Paris
Hôpital Universitaire Pitié Salpêtrière
Mansourati, Jacques
France, Brest
Centre Hospitalier Universitaire de Brest
Cöttin, Yves
France, Dijon
Hôpital François Mitterrand
Leclercq, Florence L.
Unknown Affiliation
Delarche, Nicolas
France, Pau
Centre Hospitalier de Pau
Boccara, Franck
France, Paris
Hôpital Saint-antoine
Paganelli, Franck F.
France, Marseille
Hôpital Nord Ap-hm
Clerc, Jérôme
France, Compiegne
Centre Hospitalier Compiègne
Schiele, François
France, Besancon
Hopital Jean Minjoz
Aboyans, Victor
France, Limoges
Hopital Dupuytren
Probst, Vincent
France, Nantes
Chu de Nantes
Berland, Jacques
France, Agen
Clinique Saint Hilaire
Lefévre, Thierry
France, Massy
Institut Hospitalier Jacques Cartier
Khintibidze, Irakli
Unknown Affiliation
Pagava, Zurab M.
Unknown Affiliation
Hemetsberger, Rayyan
Germany, Dortmund
St.-johannes-hospital Dortmund
Stellbrink, Christoph
Germany, Bielefeld
Klinikum Bielefeld Gem.gmbh
Zirlik, Andreas
Germany, Freiburg Im Breisgau
Universität Freiburg
Laufs, Ulrich
Germany, Homburg
Universitätsklinikum Des Saarlandes Medizinische Fakultät Der Universität Des Saarlandes
Winkelmann, Bernhard Rudolf
Unknown Affiliation
Münzel, Tomas F.
Germany, Mainz
Universitätsmedizin Mainz
Weil, Joachim
Germany, Lubeck
Sana Kliniken Lübeck
Völler, Heinz
Unknown Affiliation
Steiner, Stephan
Unknown Affiliation
Manolis, Athanasios John
Greece, Athens
Athens General Hospital
Athyros, Vasilios Gabriel
Greece, Thessaloniki
Ippokration Hospital Thessaloniki
Lekakis, John P.
Greece, Athens
Attikon University Hospital
Yan, Bryan Ping Yen
Hong Kong
Prince of Wales Hospital Hong Kong
Merkely, Béla D.Signla
Hungary, Budapest
Általános Orvostudományi Kar
Ungi, Imre
Unknown Affiliation
Édes, István Ferenc
Unknown Affiliation
Sandhu, Manjinder Singh
Unknown Affiliation
Premchand, Rajendra Kumar
Unknown Affiliation
Kerkar, Prafulla Gopinath
India, Mumbai
Seth gs Medical College and Kem Hospital
Chopra, Vijay Kumar
Unknown Affiliation
Goyal, Naresh Kumar
Unknown Affiliation
Pandurangi, Ulhas Madhukarrao
India, Chennai
Madras Medical Mission
Shechter, Michael
Unknown Affiliation
Lotan, Chaim S.
Israel, Jerusalem
Hadassah University Medical Centre
Henkin, Yaakov
Israel, Beer Sheva
Soroka University Medical Center
Klutstein, Marc W.
Israel, Jerusalem
Shaare Zedek Medical Center
Kornowski, Ran
Unknown Affiliation
Amir, Offer
Unknown Affiliation
Hussein, Osamah A.
Israel, Safad
Rebecca Sieff Hospital
Gavish, Dov
Unknown Affiliation
Vered, Zvi
Israel, Beer Yacov
Shamir Medical Center
Caraco, Yoseph
Israel, Jerusalem
Hadassah University Medical Centre
Salvioni, Alessandro
Unknown Affiliation
Musumeci, Giuseppe
Unknown Affiliation
Calabrò, Paolo
Unknown Affiliation
Novo, Salvatore
Italy, Palermo
Azienda Ospedaliera Universitaria Policlinico Paolo Giaccone
Faggiano, Pompilio Massimo
Italy, Brescia
Spedali Civili Di Brescia
Berti, Sergio
Unknown Affiliation
Cavallini, Claudio
Unknown Affiliation
Tespili, Maurizio
Unknown Affiliation
de Luca, Giuseppe
Unknown Affiliation
Perrone-Filardi, P.
Italy, Naples
Università Degli Studi Di Napoli Federico Ii
Kamiya, Haruo
Japan, Nagoya
Japanese Red Cross Nagoya Daiichi Hospital
Ando, Kenji
Japan, Kitakyushu
Kokura Kinen Hospital
Morino, Yoshihiro
Japan, Morioka
Iwate Medical University
Kimura, Kazuo
Japan, Yokohama
Yokohama City University Medical Center
Hirayama, Atsushi
Japan, Tokyo
Nihon University
Shinke, Toshiro
Japan, Kobe
Kobe University Hospital
Ako, Junya Y.
Japan, Sagamihara
Kitasato University Hospital
Sakamoto, Tomohiro
Japan, Kumamoto
Saiseikai Kumamoto Hospital
Furukawa, Yutaka
Japan, Kobe
Kobe City Medical Center General Hospital
Kim, Moo-hyun
South Korea, Busan
Dong-a University
Jeong, Myungho
South Korea, Gwangju
Chonnam National University Hospital
Rha, Seungwoon
South Korea, Seoul
Korea University
Kim, Chongjin
South Korea, Seoul
Kyung Hee Medical Center
Petrulioniene, Žaneta
Lithuania, Vilnius
Vilniaus Universitetas
Šlapikas, Rimvydas
Lithuania, Kaunas
Lietuvos Sveikatos Mokslų Universitetas
Kubilius, Raimondas
Unknown Affiliation
Ong, Tiongkiam
Malaysia, Kuching
Sarawak General Hospital
Liew, Houngbang
Malaysia, Kota Kinabalu
Hospital Queen Elizabeth Ii
Mohamed, Wan Mohd Izani
Malaysia, Kota Bharu
Hospital Universiti Sains Malaysia
Carrillo-Calvillo, Jorge
Mexico, San Luis Potosi
Hospital Central Dr. Ignacio Morines Prieto
Alcocer-Gamba, Marco Antonio
Unknown Affiliation
Suryapranata, Harry
Netherlands, Nijmegen
Radboud Universiteit
Al-Windy, Nadea Y.Y.
Unknown Affiliation
Cornel, Jan Hein
Unknown Affiliation
Hermans, Walter R.M.
Unknown Affiliation
Groutars, Reginald G.E.J.
Netherlands, Amsterdam
Olvg
Ronner, Eelko F.
Netherlands, Delft
Reinier de Graaf Hospital - Ssdz
Groenemeijer, Björn E.
Unknown Affiliation
Liem, Anho
Netherlands, Rotterdam
St. Franciscus Gasthuis
Nijmeijer, Remco
Unknown Affiliation
Willems, Frank F.
Netherlands, Arnhem
Rijnstate Hospital
Stewart, Ralph A.H.
New Zealand, Auckland
Auckland City Hospital
Nygård, Ottar Kjell
Unknown Affiliation
Gullestad, Lars Lysgaard
Norway, Oslo
Universitetet I Oslo
Blicharski, Tomasz
Poland, Swidnik
Lubelskie Centrum Diagnostyczne
Gniot, Jacek R.
Unknown Affiliation
Franek, Edward M.
Unknown Affiliation
Pereira, He´lder Horta
Portugal, Almada
Hospital Garcia de Orta
Militaru, Constantin
Unknown Affiliation
Kobalava, Zhanna D.
Unknown Affiliation
Barbarash, Olga Leonidovna
Unknown Affiliation
Vishnevsky, Alexander Yu
Russian Federation, Saint Petersburg
Pokrovskaya City Hospital
Voevoda, Michael I.
Unknown Affiliation
Baranova, Elena I.
Russian Federation, Saint Petersburg
Pavlov University
Shogenov, Zaur S.
Unknown Affiliation
Simić, Dragan Vojislav
Serbia, Belgrade
Klinicki Centar Srbije
Tasić, Nebojša M.
Unknown Affiliation
Putniković, Biljana I.
Unknown Affiliation
Seferović, Petar M.
Serbia, Belgrade
Klinicki Centar Srbije
Poh, Kiankeong
Singapore, Singapore City
National University Hospital
Pella, Daniel
Unknown Affiliation
Džupina, Andrej
Unknown Affiliation
Kamenský, Gabriel
Slovakia, Bratislava
Univ Nemocn Bratislava
Dukát, Andrej
Slovakia, Bratislava
Univ Nemocn Bratislava
Cyster, Henry P.
Unknown Affiliation
Ranjith, Naresh
Unknown Affiliation
Bayat, Junaid
Unknown Affiliation
Basson, Matthys Mde V.V.
Unknown Affiliation
van Zyl, Louis T.
Unknown Affiliation
Saaiman, Jan A.
Unknown Affiliation
Commerford, Patrick Joseph
South Africa, Observatory
Groote Schuur Hospital
Ebrahim, Iftikhar Osman
South Africa, Centurion
Netcare Unitas Hospital
Reuter, Helmuth
South Africa, Stellenbosch
Winelands Rheumatology Centre
Cequier, Ángel R.
Spain, Barcelona
Hospital Universitari de Bellvitge
Marín, F. M.
Spain, Murcia
Hospital Clínico Universitario Virgen de la Arrixaca
García-Dorado, David
Spain, Barcelona
Hospital Universitari Vall D'hebron
Íñiguez-Romo, Andrés
Unknown Affiliation
Gónzalez-Juanatey, José Ramón
Spain, Santiago de Compostela
Hospital Clínico Universitario de Santiago
Civeira, Fernando
Spain, Zaragoza
Hospital Miguel Servet
Luis Zamorano, José
Spain, Madrid
Hospital Universitario Ramón y Cajal
Díaz-Fernández, José Francisco
Spain, Huelva
Clinica de Coloproctologia Hospital Juan Romon Jimenez
González-Juanatey, Carlos
Spain, Lugo
Hospital Universitario Lucus Augusti
Jayawardena, Jayanthimala B.
Unknown Affiliation
Mendis, Sepalika
Unknown Affiliation
Senaratne, Vajira
Unknown Affiliation
Amarasena, Naomali
Unknown Affiliation
Statistics
Citations: 1,997
Authors: 336
Affiliations: 437
Identifiers
Doi:
10.1056/NEJMoa1801174
ISSN:
00284793
Research Areas
Disability
Environmental
Noncommunicable Diseases
Study Design
Cohort Study
Case-Control Study