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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
immunology and microbiology
EBV strain variation: Geographical distribution and relation to disease state
Virology, Volume 190, No. 1, Year 1992
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Description
The strains of Epstein-Barr Virus (EBV) were characterized in epithelial and lymphoid malignancies from geographic regions with high or low incidence. The predominant strains in nasopharyngeal carcinoma (NPC) from regions with elevated incidence were EBV type 1 in southeast Asia and Mediterranean Africa. In Alaskan Eskimos, a distinct variant of EBV type 2 was found in NPC and carcinoma of the parotid gland. This strain contained polymorphisms characteristic of the Asian EBV type 1. The strains prevalent in southeast Asia and Mediterranean Africa were also found in NPC which developed in caucasian Americans. These variants were not detected in lymphomas which developed in central Africa, Mediterranean Africa, or continental United States. These results suggest that distinct EBV strains predominate in geographic areas with elevated incidence of NPC. The detection of these distinct strains in epithelial tumors from areas of low incidence may reflect an epithelial cell tropism or pathogenicity. © 1992.
Authors & Co-Authors
Abdel-Hamid, Mohamed A.
United States, Chapel Hill
The University of North Carolina at Chapel Hill
Egypt, Minya
Minia University
Chen, Jian Jing
China, Guangzhou
Zhongshan School of Medicine, Sysu
Constantine, Niel T.
United States, Baltimore
University of Maryland School of Medicine
Massoud, Mohamed
Egypt, Cairo
Ain Shams University
Raab-Traub, Nancy J.
United States, Chapel Hill
The University of North Carolina at Chapel Hill
Statistics
Citations: 150
Authors: 5
Affiliations: 5
Identifiers
Doi:
10.1016/0042-6822(92)91202-6
ISSN:
00426822
e-ISSN:
10960341
Research Areas
Cancer
Study Design
Cohort Study