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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
medicine
The Schizophrenia and Bipolar Disorder associated BRD1 gene is regulated upon chronic restraint stress
European Neuropsychopharmacology, Volume 22, No. 9, Year 2012
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Description
Recent genetic evidence has implicated the bromodomain containing 1 gene (BRD1) with brain development and susceptibility to Schizophrenia and Bipolar Disorder. The BRD1 protein, which is essential for acetylation of histone H3K14, is a putative regulator of transcription during brain development and in the mature CNS. However, several issues remain to be clarified for example regarding the regulation of the BRD1 gene upon environmental interventions. Chronic restraint stress (CRS) in rats represents an environmental method for induction of morphological and functional changes in the hippocampus and the prefrontal cortex. In order to investigate whether the expression of the rat Brd1 gene may be regulated during such conditions, Brd1 mRNA and protein levels in hippocampus and prefrontal cortex extracts from rats subjected to either 1/2 or 6. h of CRS per day for 21. days were measured. We found a significant 2-fold up-regulation of long exon 7 splice variants of the Brd1 gene (Brd1-L) in hippocampus in both groups of CRS rats compared to controls. Concomitantly, we found a similar up-regulation of the BRD1 protein. In prefrontal cortex, we found no significant differences in Brd1 mRNA or protein levels. As selective histone deacetylase (HDAC) inhibitors not only preserve stress-induced hyperacetylation of histone H3K14 but also have hippocampal-dependent antidepressant-like activity, we propose that BRD1 by its intrinsic acetylation activity towards histone H3K14 is a player in the regulatory processes underlying adaptation to stress in the mature CNS. © 2012 Elsevier B.V. and ECNP.
Authors & Co-Authors
Christensen, Jane Hvarregaard
Denmark, Aarhus
Aarhus Universitet
Elfving, Betina
Denmark, Aarhus
Aarhus Universitetshospital
Müller, Heidi Kaastrup
Denmark, Aarhus
Aarhus Universitetshospital
Fryland, Tue
Denmark, Aarhus
Aarhus Universitet
Nyegaard, Mette
Denmark, Aarhus
Aarhus Universitet
Corydon, Thomas J.
Denmark, Aarhus
Aarhus Universitet
Nielsen, Anders Lade
Denmark, Aarhus
Aarhus Universitet
Mors, Ole N.
Denmark, Aarhus
Aarhus Universitetshospital
Wegener, Gregers
Denmark, Aarhus
Aarhus Universitetshospital
South Africa, Potchefstroom
North-west University
BØRglum, Anders Dupont
Denmark, Aarhus
Aarhus Universitet
Denmark, Aarhus
Aarhus Universitetshospital
Statistics
Citations: 28
Authors: 10
Affiliations: 3
Identifiers
Doi:
10.1016/j.euroneuro.2012.01.005
ISSN:
0924977X
e-ISSN:
18737862
Research Areas
Genetics And Genomics
Mental Health