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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
biochemistry, genetics and molecular biology
Stage-specific sampling by pattern recognition receptors during Candida albicans phagocytosis
PLoS Pathogens, Volume 4, No. 11, Article e1000218, Year 2008
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Description
Candida albicans is a medically important pathogen, and recognition by innate immune cells is critical for its clearance. Although a number of pattern recognition receptors have been shown to be involved in recognition and phagocytosis of this fungus, the relative role of these receptors has not been formally examined. In this paper, we have investigated the contribution of the mannose receptor, Dectin-1, and complement receptor 3; and we have demonstrated that Dectin-1 is the main non-opsonic receptor involved in fungal uptake. However, both Dectin-1 and complement receptor 3 were found to accumulate at the site of uptake, while mannose receptor accumulated on C. albicans phagosomes at later stages. These results suggest a potential role for MR in phagosome sampling; and, accordingly, MR deficiency led to a reduction in TNF-a and MCP-1 production in response to C. albicans uptake. Our data suggest that pattern recognition receptors sample the fungal phagosome in a sequential fashion. © 2008 Heinsbroek et al.
Available Materials
https://efashare.b-cdn.net/share/pmc/articles/PMC2583056/bin/ppat.1000218.s001.pdf
https://efashare.b-cdn.net/share/pmc/articles/PMC2583056/bin/ppat.1000218.s002.pdf
https://efashare.b-cdn.net/share/pmc/articles/PMC2583056/bin/ppat.1000218.s003.pdf
Authors & Co-Authors
Heinsbroek, Sigrid E.M.
United Kingdom, Oxford
Sir William Dunn School of Pathology
Netherlands, Amsterdam
Universiteit Van Amsterdam
Taylor, Philip Russel
United Kingdom, Oxford
Sir William Dunn School of Pathology
United Kingdom, Cardiff
Cardiff University School of Medicine
Martinez, Fernando O.
United Kingdom, Oxford
Sir William Dunn School of Pathology
Martinez-Pomares Luisa, Luisa
United Kingdom, Oxford
Sir William Dunn School of Pathology
United Kingdom, Nottingham
University of Nottingham
Brown, Gordon D.A.
South Africa, Cape Town
University of Cape Town
Gordon, Siamon
United Kingdom, Oxford
Sir William Dunn School of Pathology
Statistics
Citations: 123
Authors: 6
Affiliations: 5
Identifiers
Doi:
10.1371/journal.ppat.1000218
ISSN:
15537366
e-ISSN:
15537374