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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
medicine
Cytokine profiles in peripheral, placental and Cord blood in an area of Unstable malaria transmission in Eastern Sudan
Journal of Tropical Pediatrics, Volume 55, No. 4, Year 2009
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Description
Background: Understanding the cytokine interactions that underlie both control and disease should be helpful when investigating the pathogenesis of malaria during pregnancy. Few data exists concerning pathogenesis of malaria during pregnancy in areas of unstable malaria transmission. Objectives: The study was conducted in New Halfa hospital, eastern Sudan, which is characterized by unstable malaria transmission to investigate the cytokine profiles in peripheral, placental and cord blood in parturient women. Methods: Enzyme-linked immunosorbent assay was used to measure the concentrations of three cytokines, interferon-γ (IFN-γ), interleukin-4 (IL-4) and IL-10, in sera from peripheral, placental and cord blood of 87 Sudanese women. Results: The concentrations of these cytokines were significantly higher in peripheral, placental sera from uninfected women than in sera from infected women. IFN-γ concentrations were significantly lower in the cord sera from uninfected women in comparison to the infected ones. The levels of these cytokines were not significantly different between the primiparae and multipare. Cord sera in all groups showed lower levels of these cytokines. Strong positive correlations were observed between peripheral and placental cytokines. Conclusion: The immune responses that occur in placental, peripheral and cord blood were influenced by the malaria infections, irrespective of the parity. The immune response during Plasmodium falciparum infection is not different in the peripheral and placental compartments, further studies are required. © The Author [2008]. Published by Oxford University Press. All rights reserved.
Authors & Co-Authors
Bayoumi, N. K.
Sudan, Khartoum
University of Khartoum Faculty of Medicine
Bakhet, Khalid H.
Sudan, Khartoum
University of Khartoum Faculty of Medicine
Mohmmed, Ahmed A.
Sudan, Khartoum
National Ribat University
Eltom, Ahmed Mohamedain
Sudan, Khartoum
University of Khartoum Faculty of Medicine
Elbashir, Mustafa Idris
Sudan, Khartoum
University of Khartoum Faculty of Medicine
Mavoungou, Elie
Germany, Tubingen
Eberhard Karls Universität Tübingen
Gabon, Lambarene
Unité de Recherche Médicale, Albert Schweitzer Hospital
Adam, Ishag I.
Sudan, Khartoum
University of Khartoum Faculty of Medicine
Statistics
Citations: 32
Authors: 7
Affiliations: 4
Identifiers
Doi:
10.1093/tropej/fmn062
ISSN:
01426338
e-ISSN:
14653664
Research Areas
Health System And Policy
Infectious Diseases
Maternal And Child Health
Sexual And Reproductive Health
Study Locations
Sudan
Participants Gender
Female