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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
medicine
Preimplantation genetic screening for aneuploidy of embryos after in vitro fertilization in women aged at least 35 years: a prospective randomized trial
Fertility and Sterility, Volume 93, No. 2, Year 2010
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Description
Objective: To test the hypothesis that patients with advanced maternal age (AMA) have a higher implantation rate (IR) after embryo transfer of embryos with a normal chromosomal pattern for the chromosomes studied with preimplantation genetic screening (PGS) compared with patients who had an embryo transfer without PGS. Design: Prospective randomized controlled trial (RCT). Setting: Academic tertiary setting. Patient(s): Patients with AMA (≥35 years). Intervention(s): In an RCT, the clinical IR per embryo transferred was compared after embryo transfer on day 5 or 6 between the PGS group (analysis of chromosomes 13, 16, 18, 21, 22, X, and Y) and the Control group without PGS. Main Outcome Measure(s): No differences were observed between the PGS group and the Control group for the clinical IR (15.1%; 14.9%; rate ratio 1.01; exact confidence interval [CI], 0.25-5.27), the ongoing IR (at 12 weeks) (9.4%; 14.9%), and the live born rate per embryo transferred (9.4%; 14.9%; rate ratio 0.63; exact CI, 0.08-3.37). Fewer embryos were transferred in the PGS group (1.6 ± 0.6) than in the Control group (2.0 ± 0.6). A normal diploid status was observed in 30.3% of the embryos screened by PGS. Conclusion(s): In this RCT, the results did not confirm the hypothesis that PGS results in improved reproductive outcome in patients with AMA. © 2010 American Society for Reproductive Medicine.
Authors & Co-Authors
Debrock, Sophie
Belgium, Leuven
Ku Leuven
Spiessens, Carl S.
Belgium, Leuven
Ku Leuven
Peeraer, Karen
Belgium, Leuven
Ku Leuven
Meuleman, Christel L.
Belgium, Leuven
Ku Leuven
Vermeesch, Joris Robert
Belgium, Leuven
Centrum Menselijke Erfelijkheid
D'Hooghe, Thomas Maria
Belgium, Leuven
Centrum Menselijke Erfelijkheid
Statistics
Citations: 135
Authors: 6
Affiliations: 2
Identifiers
Doi:
10.1016/j.fertnstert.2008.10.072
ISSN:
00150282
Research Areas
Genetics And Genomics
Health System And Policy
Maternal And Child Health
Sexual And Reproductive Health
Study Design
Randomised Control Trial
Cohort Study
Study Approach
Quantitative
Participants Gender
Female