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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
biochemistry, genetics and molecular biology
Association of SGK1 gene polymorphisms with type 2 diabetes
Cellular Physiology and Biochemistry, Volume 21, No. 1-3, Year 2008
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Description
The serum and glucocorticoid inducible kinase SGK1 is genomically upregulated by glucocorticoids and in turn stimulates a variety of carriers and channels including the renal epithelial Na + channel ENaC and the intestinal Na + glucose transporter SGLT1. Twin studies disclosed an association of a specific SGK1 haplotype with moderately enhanced blood pressure in individuals who are carrying simultaneously a homozygous genotype for a variant in intron 6 [I6CC] and a homozygous or heterozygous genotype for the C allele of a polymorphism in exon 8 [E8CC/CT] of the SGK1 gene. A subsequent study confirmed the impact of this risk haplotype on blood pressure. SGK1 knockout mice are resistant to the insulin and high salt induced increase of blood pressure, glucocorticoid induced increase of electrogenic glucose transport, and glucocorticoid induced suppression of insulin release. The present study explored whether the I6CC/E8CC/CT haplotype impacts on the prevalence of type 2 diabetes. The prevalence of the I6CC genotype was 3.1% in a healthy German, 2.4 % in a healthy Romanian and 11.6 % in a healthy African population from Ghana (p=0.0006 versus prevalence in Caucasians). Comparison of genotype frequencies between type 2 diabetic patients and the respective control groups revealed significant differences for the intron 6 T>C variant. Carriers of at least one T allele were protected against type 2 diabetes (Romanians: p=0.023; OR 0.29; 95% CI 0.09-0.89; Germans: p=0.01; OR 0.37; 95% CI 0.17-0.81). The SGK1 risk haplotype (I6CC/E8CC/CT) was significantly (p=0.032; OR 4.31, 95% CI 1.19-15.58) more frequent in diabetic patients (7.2 %) than in healthy volunteers from Romania (1.8%). The observations support the view that SGK-1 may participate in the pathogenesis of metabolic syndrome. Copyright © 2008 S. Karger AG.
Authors & Co-Authors
Schwab, Matthias M.
Germany, Stuttgart
Dr. Margarete Fischer-bosch-institut Für Klinische Pharmakologie
Germany, Tubingen
Eberhard Karls Universität Tübingen
Lupescu, Adrian
Germany, Tubingen
Eberhard Karls Universität Tübingen
Moţa, Maria F.A.
Romania, Craova
Universitatea de Medicină şi Farmacie Din Craiova
Moţa, Eugen S.
Romania, Craova
Universitatea de Medicină şi Farmacie Din Craiova
Frey, Andreas
Germany, Tubingen
Eberhard Karls Universität Tübingen
Simon, Perikles
Germany, Tubingen
Eberhard Karls Universität Tübingen
Mertens, Peter R.
Germany, Aachen
Rheinisch-westfälische Technische Hochschule Aachen
Floege, Jürgen
Germany, Aachen
Rheinisch-westfälische Technische Hochschule Aachen
Luft, Friedrich C.
Germany, Berlin
Humboldt-universität zu Berlin
Asante-Poku, Steven
Ghana, Accra
University of Ghana
Schaeffeler, Elke E.
Germany, Stuttgart
Dr. Margarete Fischer-bosch-institut Für Klinische Pharmakologie
Germany, Tubingen
Eberhard Karls Universität Tübingen
Lang, Florian C.
Germany, Tubingen
Eberhard Karls Universität Tübingen
Statistics
Citations: 61
Authors: 12
Affiliations: 6
Identifiers
Doi:
10.1159/000113757
ISSN:
10158987
Research Areas
Genetics And Genomics
Noncommunicable Diseases
Study Design
Cross Sectional Study
Study Locations
Ghana