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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
medicine
Soluble Tumor Necrosis Factor Receptors Correlate with Parasitemia and Disease Severity in Human Malaria
Journal of Infectious Diseases, Volume 166, No. 4, Year 1992
Notification
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Description
Elevated serum or plasma concentration of immunoreactive tumor necrosis factor (TNF) is consistently detected in patients with malaria. TNF levels correlate with high parasitemia and clinical severity but not always with outcome. Since the effects of TNF may be neutralized by soluble TNF receptors, sera of 30 nonimmune patients with malaria were analyzed before and during antimalarial therapy. High concentrations of receptors R1 (55 kDa) and R2 (75 kDa) were detected immunologically in all sera of untreated patients. Levels of immunoreactive TNF correlated closely with levels of soluble TNF R1 and R2 (r =.75 and.59, respectively). In contrast, sera lacked cytotoxic activity against target cells in the TNF bioassays. Soluble TNF receptor levels remained elevated for days after treatment. These results suggest that excessive release of TNF induced by the asexual stage of malaria parasites is controlled by a subsequent shedding of soluble TNF receptors that may bind and deactivate biologically functional TNF. © 1992 The University of Chicago.
Authors & Co-Authors
Kern, Peter M.
Germany, Ulm
Universität Ulm
Switzerland, Basel
F. Hoffmann-la Roche ag
Hemmer, Christoph Josef
Germany, Ulm
Universität Ulm
Switzerland, Basel
F. Hoffmann-la Roche ag
Neifer, Stefan
Germany, Ulm
Universität Ulm
Switzerland, Basel
F. Hoffmann-la Roche ag
Kremsner, Peter G.
Germany, Ulm
Universität Ulm
Switzerland, Basel
F. Hoffmann-la Roche ag
Dietrich, Manfred
Germany, Ulm
Universität Ulm
Switzerland, Basel
F. Hoffmann-la Roche ag
Statistics
Citations: 108
Authors: 5
Affiliations: 2
Identifiers
Doi:
10.1093/infdis/166.4.930
ISSN:
00221899
Research Areas
Cancer
Infectious Diseases