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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
biochemistry, genetics and molecular biology
A schizont-derived protein, TpSCOP, is involved in the activation of NF-κB in Theileria parva-infected lymphocytes
Molecular and Biochemical Parasitology, Volume 174, No. 1, Year 2010
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Description
Theileria parva is a tick-transmitted intracellular protozoan parasite that causes East Coast fever, a fatal bovine lymphoproliferative disease. The molecular mechanisms that underlie host cell transformation by T. parva schizonts have been studied extensively, and it is known that the nuclear factor-kappa B (NF-κB) is activated in schizont-infected cells, making T. parva-transformed cells resistant to apoptosis. However, the mechanism by which the parasite triggers the activation of NF-κB remains enigmatic. Inthe present study, we biochemically characterized a novel protein, which we termed TpSCOP (T. parva schizont-derived cyt. oskeleton-binding protein), which is expressed in the schizont stage of T. parva. TpSCOP was shown to interact with F-actin in vitro. Expression of TpSCOP in a murine lymphocytic cell line resulted in the activation of NF-κB signaling pathways, leading to apoptosis resistance. The activation of mitogen-activated protein kinase (MAPK), including extracellular signal-regulated kinase (ERK) and c-Jun N-terminal kinase (JNK), was also detected. Furthermore, the introduction of TpSCOP into T. parva-infected cells also enhanced the activation of NF-κB. This is the first report to demonstrate that a parasite-derived molecule has the ability to activate the host NF-κB pathway. Based on these results, TpSCOP likely plays an important role in apoptosis inhibition during Theileria infection. © 2010 Elsevier B.V.
Authors & Co-Authors
Hayashida, Kyouko
Japan, Sapporo
Hokkaido University
Hattori, Masakazu
Japan, Tokyo
Kitasato University
Nakao, Ryo
Japan, Sapporo
Hokkaido University
Tanaka, Yoshimasa
Japan, Kyoto
Kyoto University
Kim, Jung Yeon
South Korea, Cheongju
Korea Disease Control and Prevention Agency
Inoue, Noboru I.
Japan, Obihiro
Obihiro University of Agriculture and Veterinary Medicine
Nene, Vishvanath M.
Kenya, Nairobi
International Livestock Research Institute Nairobi
Sugimoto, Chihiro
Japan, Sapporo
Hokkaido University
Statistics
Citations: 13
Authors: 8
Affiliations: 6
Identifiers
Doi:
10.1016/j.molbiopara.2010.06.005
ISSN:
01666851
Research Areas
Cancer