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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
biochemistry, genetics and molecular biology
Promoter hypermethylation and suppression of glutathione peroxidase 3 are associated with inflammatory breast carcinogenesis
Oxidative Medicine and Cellular Longevity, Volume 2014, Article 787195, Year 2014
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Description
Reactive oxygen species (ROS) play a crucial role in breast cancer initiation, promotion, and progression. Inhibition of antioxidant enzymes that remove ROS was found to accelerate cancer growth. Studies showed that inhibition of glutathione peroxidase-3 (GPX3) was associated with cancer progression. Although the role of GPX3 has been studied in different cancer types, its role in breast cancer and its epigenetic regulation have not yet been investigated. The aim of the present study was to investigate GPX3 expression and epigenetic regulation in carcinoma tissues of breast cancer patients' in comparison to normal breast tissues. Furthermore, we compared GPX3 level of expression and methylation status in aggressive phenotype inflammatory breast cancer (IBC) versus non-IBC invasive ductal carcinoma (IDC). We found that GPX3 mRNA and protein expression levels were downregulated in the carcinoma tissues of IBC compared to non-IBC. However, we did not detect significant correlation between GPX3 and patients' clinical-pathological prosperities. Promoter hypermethylation of GPX3 gene was detected in carcinoma tissues not normal breast tissues. In addition, IBC carcinoma tissues showed a significant increase in the promoter hypermethylation of GPX3 gene compared to non-IBC. Our results propose that downregulation of GPX3 in IBC may play a role in the disease progression. © 2014 Mona M. Mohamed et al.
Authors & Co-Authors
Mohamed, Mona M.
Egypt, Giza
Faculty of Science
Sabet, Salwa Farouk
Egypt, Giza
Faculty of Science
Peng, Dunfa
United States, Nashville
Vanderbilt University Medical Center
Nouh, M. Akram
Egypt, Giza
National Cancer Institute
El-Shinawi, Mohamed
Egypt, Cairo
Faculty of Medicine - Ain Shams University
El-Rifai, Wa’el M.
United States, Nashville
Vanderbilt University Medical Center
Statistics
Citations: 50
Authors: 6
Affiliations: 4
Identifiers
Doi:
10.1155/2014/787195
e-ISSN:
19420994
Research Areas
Cancer
Genetics And Genomics