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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
biochemistry, genetics and molecular biology
Cytotoxic and PTP1B inhibitory activities from Erythrina abyssinica
Bioorganic and Medicinal Chemistry Letters, Volume 19, No. 23, Year 2009
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Description
Bioassay-guided fractionation of the EtOAc extract of the stem bark of Erythrina abyssinica (Leguminosae) resulted in the isolation of three new (1-3), along with 12 known (4-15) pterocarpan derivatives. Their chemical structures were determined by physicochemical and spectroscopic data analysis (IR, UV, [α]D, CD, 1D and 2D NMR, and MS data). All the isolates were evaluated for their inhibitory effects on protein tyrosine phosphatase-1B (PTP1B), as well as their growth inhibition on MCF7, tamoxifen-resistant MCF7 (MCF7/TAMR), adriamycin-resistant MCF7 (MCF7/ADR) and MDA-MB-231 breast cancer cell lines. Compounds which exhibited PTP1B inhibitory activity (IC50 values ranging from 4.2 ± 0.2 to 19.3 ± 0.3 μM) showed strong cytotoxic activity (IC50 values from 5.6 ± 0.7 to 28.0 ± 0.2 μM). Our data suggested that pterocarpans could be considered as new anticancer materials by PTP1B inhibition. © 2009 Elsevier Ltd. All rights reserved.
Authors & Co-Authors
Nguyen, Phi Hung H.
South Korea, Gwangju
Chosun University
Le, Thi Van Thu
South Korea, Gwangju
Chosun University
Thuong, Phuong Thien
South Korea, Gwangju
Chosun University
Dao, Trong Tuan
South Korea, Gwangju
Chosun University
Tantoh Ndinteh, Derek Tantoh
Cameroon, Yaounde
Université de Yaoundé I
Mbafor, Joseph Tanyi
Cameroon, Yaounde
Université de Yaoundé I
Kang, Keonwook
South Korea, Gwangju
Chosun University
Oh, Won Keun
South Korea, Gwangju
Chosun University
Statistics
Citations: 43
Authors: 8
Affiliations: 2
Identifiers
Doi:
10.1016/j.bmcl.2009.09.108
ISSN:
0960894X
Research Areas
Cancer