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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
medicine
Global burden of acute lower respiratory infections due to respiratory syncytial virus in young children: a systematic review and meta-analysis
The Lancet, Volume 375, No. 9725, Year 2010
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Description
Background: The global burden of disease attributable to respiratory syncytial virus (RSV) remains unknown. We aimed to estimate the global incidence of and mortality from episodes of acute lower respiratory infection (ALRI) due to RSV in children younger than 5 years in 2005. Methods: We estimated the incidence of RSV-associated ALRI in children younger than 5 years, stratified by age, using data from a systematic review of studies published between January, 1995, and June, 2009, and ten unpublished population-based studies. We estimated possible boundaries for RSV-associated ALRI mortality by combining case fatality ratios with incidence estimates from hospital-based reports from published and unpublished studies and identifying studies with population-based data for RSV seasonality and monthly ALRI mortality. Findings: In 2005, an estimated 33·8 (95% CI 19·3-46·2) million new episodes of RSV-associated ALRI occurred worldwide in children younger than 5 years (22% of ALRI episodes), with at least 3·4 (2·8-4·3) million episodes representing severe RSV-associated ALRI necessitating hospital admission. We estimated that 66 000-199 000 children younger than 5 years died from RSV-associated ALRI in 2005, with 99% of these deaths occurring in developing countries. Incidence and mortality can vary substantially from year to year in any one setting. Interpretation: Globally, RSV is the most common cause of childhood ALRI and a major cause of admission to hospital as a result of severe ALRI. Mortality data suggest that RSV is an important cause of death in childhood from ALRI, after pneumococcal pneumonia and Haemophilus influenzae type b. The development of novel prevention and treatment strategies should be accelerated as a priority. Funding: WHO; Bill & Melinda Gates Foundation. © 2010 Elsevier Ltd. All rights reserved.
Available Materials
https://efashare.b-cdn.net/share/pmc/articles/PMC2864404/bin/mmc1.pdf
Authors & Co-Authors
Nair, Harish
United Kingdom, Edinburgh
The University of Edinburgh
India, New Delhi
Public Health Foundation of India
Nokes, David James
Kenya, Kilifi
Centre for Geographic Medicine Research
United Kingdom, Coventry
University of Warwick
Gessner, Bradford D.
France, Paris
Agence de Médecine Préventive
Dherani, Mukesh K.
United Kingdom, Liverpool
University of Liverpool
Madhi, Shabir A.
South Africa, Johannesburg
University of the Witwatersrand
Singleton, Rosalyn J.
United States, Anchorage
Alaska Native Tribal Health Consortium
United States, Atlanta
National Center for Infectious Diseases
O'Brien, Katherine L.
United States, Baltimore
Johns Hopkins Bloomberg School of Public Health
Roca, Anna
Spain, Barcelona
Hospital Clinic Barcelona
Mozambique, Manhica
Centro de Investigação em Saúde de Manhiça Cism
Wright, Peter F.
United States, Hanover
Geisel School of Medicine at Dartmouth
Bruce, Nigel G.
United Kingdom, Liverpool
University of Liverpool
Chandran, Aruna
United States, Baltimore
Johns Hopkins Bloomberg School of Public Health
Theodoratou, Evropi
United Kingdom, Edinburgh
The University of Edinburgh
Sutanto, Agustinus
Indonesia
West Nusa Tenggara Provincial Government
Sedyaningsih, Endang R.
Indonesia, Jakarta
Kementerian Kesehatan Republik Indonesia
Ngama, Mwanajuma J.
Kenya, Kilifi
Centre for Geographic Medicine Research
Munywoki, Patrick Kiio
Kenya, Kilifi
Centre for Geographic Medicine Research
Kartasasmita, Cissy Bana
Indonesia, Bandung
Universitas Padjadjaran
Simoẽs, Eric A.F.
United States, Denver
University of Colorado Denver
Rudan, Igor
United Kingdom, Edinburgh
The University of Edinburgh
Croatia, Split
School of Medicine, University of Split
Weber, Martin Willi
Indonesia, Jakarta
World Health Organization, Indonesia
Campbell, Harry
United Kingdom, Edinburgh
The University of Edinburgh
Statistics
Citations: 21
Authors: 21
Affiliations: 19
Identifiers
Doi:
10.1016/S0140-6736(10)60206-1
ISSN:
01406736
Research Areas
Health System And Policy
Maternal And Child Health
Study Design
Cross Sectional Study
Cohort Study
Study Approach
Systematic review