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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
chemistry
A novel anti-tumor agent, Ln(III) 2-thioacetate benzothiazole induces anti-angiogenic effect and cell death in cancer cell lines
European Journal of Medicinal Chemistry, Volume 51, Year 2012
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Description
New complexes with a potent DNA-binding anti-tumor agent, europium(III)- and terbium(III)-2-thioacetate benzothiazole were synthesized and characterized. These complexes showed strong binding affinity to calf thymus DNA using fluorometric and electronic absorption spectroscopy. The synthesized complexes resulted in inhibition of proliferation of EAC cells and ascites formation. Their anti-tumor effect was found to be through anti-angiogenic activity as was evident by the reduction of microvessel density and down-regulation of VEGF receptor type-2 (Flk-1). It was found that EAC cells had distinct DNA fragmentation patterns analyzed by capillary electrophoresis in the treated animals. Moreover, the synthesized complexes exhibited significant cytotoxic activity against HepG2 and MCF7 cell lines. Furthermore, complexes showed a potent anti-bacterial activity against two pathogenic bacteria Escherichia coli and Salmonella. © 2012 Elsevier Masson SAS. All rights reserved.
Authors & Co-Authors
Hussein, Belal H.M.
Egypt, Ismailia
Faculty of Science
Azab, Hassan Ahmed
Egypt, Ismailia
Faculty of Science
El-Azab, Mona F.
Egypt, Ismailia
Faculty of Pharmacy
El-Falouji, Abdullah I.
Egypt, Ismailia
Suez Canal University
Statistics
Citations: 40
Authors: 4
Affiliations: 3
Identifiers
Doi:
10.1016/j.ejmech.2012.02.025
ISSN:
02235234
e-ISSN:
17683254
Research Areas
Cancer
Genetics And Genomics
Infectious Diseases