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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
immunology and microbiology
Efficacy of the immunoblot assay for cysticercosis in pigs and modulated expression of distinct IgM/ IgG activities to Taenia solium antigens in experimental infections
Veterinary Immunology and Immunopathology, Volume 29, No. 1-2, Year 1991
Notification
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Description
A recently invented immunoblot assay for human cysticercosis was evaluated for efficacy in pigs. The test population consists of 45 pigs with parasitologically confirmed cysticercosis, 47 with heterologous infections, 45 SPF or concrete raised control animals. With this group of 137 animals the test performance was 100% sensitive and 100% specific. The antigen-specific responses of immunoglobulin A (IgA), IgG and IgM in four pigs infected with Taenia solium eggs derived from a human were quantified by immunoblot. Antigen-specific activities were observed as early as 1 week postinfection. The first antigen-specific isotypic response was IgM antibodies directed against a glycoprotein at 97 KD (GP97). This activity generally disappeared between the sixth and ninth week postinfection. Between Weeks 5 and 8, IgG activity rose as IgM activity fell. The IgG activity, however, was directed mostly towards GP50 and GP42 antigens. If the same response occurs in people with cysticercosis, identifying specific isotype activity may help to distinguish new infection from old. © 1991.
Authors & Co-Authors
Tsang, Victor C.W.
United States, Atlanta
National Center for Infectious Diseases
Pilcher, Joy A.
United States, Atlanta
National Center for Infectious Diseases
Zhou, Wei
United States, Atlanta
National Center for Infectious Diseases
Boyer, Anne E.
United States, Atlanta
National Center for Infectious Diseases
Kamango-Sollo, Ernest I.P.
Kenya, Nairobi
University of Nairobi
Rhoads, Marcia L.
United States, Beltsville
Usda Ars Beltsville Agricultural Research Center
Murrell, Kenneth Darwin
United States, Beltsville
Usda Ars Beltsville Agricultural Research Center
Schantz, Peter Mullineaux
United States, Atlanta
National Center for Infectious Diseases
Gilman, Robert Hugh
United States, Baltimore
Johns Hopkins Bloomberg School of Public Health
Statistics
Citations: 80
Authors: 9
Affiliations: 4
Identifiers
Doi:
10.1016/0165-2427(91)90053-F
ISSN:
01652427
Study Design
Cross Sectional Study