Skip to content
Home
About Us
Resources
Profiles Metrics
Authors Directory
Institutions Directory
Top Authors
Top Institutions
Top Sponsors
AI Digest
Contact Us
Menu
Home
About Us
Resources
Profiles Metrics
Authors Directory
Institutions Directory
Top Authors
Top Institutions
Top Sponsors
AI Digest
Contact Us
Home
About Us
Resources
Profiles Metrics
Authors Directory
Institutions Directory
Top Authors
Top Institutions
Top Sponsors
AI Digest
Contact Us
Menu
Home
About Us
Resources
Profiles Metrics
Authors Directory
Institutions Directory
Top Authors
Top Institutions
Top Sponsors
AI Digest
Contact Us
Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
immunology and microbiology
Chloroquine treatment of falciparum malaria in an area of kenya of intermediate chloroquine resistance
Transactions of the Royal Society of Tropical Medicine and Hygiene, Volume 82, No. 6, Year 1988
Notification
URL copied to clipboard!
Description
106 children aged 1–10 years who had pure Plasmodium falciparum infections and temperatures ⩾38 °C were treated with chloroquine base, 25 mg/kg body weight. 29% of the infections were sensitive in vivo, 41% recurred within 4 weeks (RI), 26% were RII resistant, and 4% were RIII resistant. Rieckmann micro in vitro tests were successful in 64% of isolates obtained from these children; 63% were resistant to chloroquine. In 58 paired isolates obtained before and after treatment, the level of chloroquine sensitivity was lower in the parasites persisting or recurring after treatment. All children except 2 of the 4 with RIII resistance became afebrile an average of 1–4 d after starting treatment and their other symptoms resolved in an average of 1·8 d. By day 28, 57% of the children with RI resistance and 78% of those with RII resistance had recurrence of fever and other symptoms, compared with 19% of children with sensitive infections. No relationship was observed between the clinical or parasitological response and age, nutritional status, haematocrit, splenomegaly, presence of sickle-cell trait, or seropositivity to malaria by enzyme-linked immunosorbent assay. The study demonstrates that, in most children with malaria in an area of intermediate chloroquine resistance, fever and other symptoms resolve at least temporarily when treated with chloroquine. © 1988 Oxford University Press.
Authors & Co-Authors
Brandling-Bennett, A. David
Kenya, Nairobi
Kenya Medical Research Institute
United States, Atlanta
National Center for Infectious Diseases
Oloo, Aggrey James
Kenya, Nairobi
Kenya Medical Research Institute
Watkins, Williams M.
Kenya, Nairobi
Kenya Medical Research Institute
Kenya, Nairobi
Wellcome Trust Research Laboratories Nairobi
Boriga, David A.
Kenya, Nairobi
Kenya Medical Research Institute
Kariuki, Daniel M.
Kenya, Nairobi
Kenya Medical Research Institute
Collins, Williams E.
Kenya, Nairobi
Wellcome Trust Research Laboratories Nairobi
Statistics
Citations: 49
Authors: 6
Affiliations: 3
Identifiers
Doi:
10.1016/0035-9203(88)90009-0
ISSN:
00359203
e-ISSN:
18783503
Research Areas
Infectious Diseases
Maternal And Child Health
Study Locations
Kenya