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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
medicine
Elevated T cell counts and RANTES expression in the genital mucosa of HIV-1-resistant Kenyan commercial sex workers
Journal of Infectious Diseases, Volume 192, No. 5, Year 2005
Notification
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Description
The initial site of exposure to human immunodeficiency virus (HIV)-1 during heterosexual transmission occurs in the genital tract. Although the majority of immunological studies have focused on the immune response to HIV-1 at the systemic level, our understanding of tissue-specific immunity is deficient. The goal of the present study was to characterize T cell populations found in the cervix of women shown to be resistant to infection by HIV-1. Levels of both systemic and cervical mucosal lymphocytes were compared between HIV-1-resistant, HIV-1-uninfected, and HIV-1-infected commercial sex workers (CSWs) as well as HIV-1-uninfected non-CSW control subjects at low risk for exposure. The HIV-1-resistant CSWs had increased cervical CD4+ and CD8+ T cell counts, compared with the HIV-1-uninfected CSWs; importantly, these increases were not reflected in the systemic lymphocyte compartment. There was a 2-fold increase in CD4+ T cell counts in the HIV-1-resistant CSWs, compared with both the HIV-1-infected and the HIV-1-uninfected CSWs. Expression of the HIV-1 coreceptors CCR5 and CXCR4 was also determined, and cytokine and β chemokine levels in the genital mucosa were assessed. The HIV-1-resistant CSWs had a 10-fold increase in RANTES expression, compared with the HIV-1-uninfected CSWs. This is the first study to show elevated levels of β chemokines and CD4+ T cells in the genital tracts of women who are exposed to HIV-1 and yet are uninfected. © 2005 by the Infectious Diseases Society of America. All rights reserved.
Authors & Co-Authors
Iqbal, Shehzad M.
Canada, Winnipeg
Max Rady College of Medicine, University of Manitoba
Ball, Terry Blake
Canada, Winnipeg
Max Rady College of Medicine, University of Manitoba
Kimani, Joshua
Kenya, Nairobi
University of Nairobi
Kiama, Peter
Kenya, Nairobi
University of Nairobi
Thottingal, Paul
Canada, Winnipeg
Max Rady College of Medicine, University of Manitoba
Kenya, Nairobi
University of Nairobi
Embreé, Joanne E.
Canada, Winnipeg
Max Rady College of Medicine, University of Manitoba
Fowke, Keith Raymond
Canada, Winnipeg
Max Rady College of Medicine, University of Manitoba
Plummer, Francis Allan
Canada, Winnipeg
Max Rady College of Medicine, University of Manitoba
Canada, Winnipeg
National Microbiology Laboratory
Kenya, Nairobi
University of Nairobi
Canada, Winnipeg
University of Manitoba
Statistics
Citations: 110
Authors: 8
Affiliations: 4
Identifiers
Doi:
10.1086/432482
ISSN:
00221899
Research Areas
Infectious Diseases
Sexual And Reproductive Health
Participants Gender
Female