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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
Vitamin D status of HIV-infected women and its association with hiv disease progression, anemia, and mortality
PLoS ONE, Volume 5, No. 1, Article e8770, Year 2010
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Description
Background: Vitamin D has a potential role in slowing HIV disease progression and preventing mortality based on its extensive involvement in the immune system; however, this relationship has not been examined in large studies or in resource-limited settings. Methodology/Principal Findings:Vitamin D levels were assessed in 884 HIV-infected pregnant women at enrollment in a trial of multivitamin supplementation (not including vitamin D) in Tanzania. Women were followed up for a median of 69.5 months, and information on hemoglobin levels, HIV disease progression, and mortality was recorded. Proportional hazard models and generalized estimating equations were used to assess the relationship of these outcomes with vitamin D status. Conclusions/Significance: Low vitamin D status (serum 25-hydroxyvitamin D<32ng/mL) was significantly associated with progression to WHO HIV disease stage III or greater in multivariate models (incidence rate ratio [RR]: 1.25; 95% confidence intervals [CI]: 1.05, 1.50). No significant relationship was observed between vitamin D status and T-cell counts during followup. Women with low vitamin D status had 46% higher risk of developing severe anemia during follow-up, compared to women with adequate vitamin D levels (RR: 1.46; 95% CI: 1.09, 1.96). Women in the highest vitamin D quintile had a 42% lower risk of all-cause mortality, compared to the lowest quintile (RR: 0.58; 95% CI: 0.40, 0.84). Vitamin D status had a protective association with HIV disease progression, all-cause mortality, and development of anemia during follow-up in HIV-infected women. If confirmed in randomized trials, vitamin D supplementation could represent a simple and inexpensive method to prolonging the time to initiation of antiretroviral therapy in HIV-infected patients, particularly in resource-limited settings. © 2010 Mehta et al.
Authors & Co-Authors
Mehta, Saurabh
United States, Boston
Harvard T.h. Chan School of Public Health
Giovannucci, Edward Luciano
United States, Boston
Harvard T.h. Chan School of Public Health
United States, Boston
Brigham and Women's Hospital
Mugusi, Ferdinand M.
Tanzania, Dar es Salaam
Muhimbili University of Health and Allied Sciences
Spiegelman, Donna L.
United States, Boston
Harvard T.h. Chan School of Public Health
Aboud, Said
Tanzania, Dar es Salaam
Muhimbili University of Health and Allied Sciences
Hertzmark, Ellen
United States, Boston
Harvard T.h. Chan School of Public Health
Msamanga, Gernard I.
Tanzania, Dar es Salaam
Muhimbili University of Health and Allied Sciences
Hunter, D. J.
United States, Boston
Harvard T.h. Chan School of Public Health
United States, Boston
Brigham and Women's Hospital
Fawzi, Wafaie W.
United States, Boston
Harvard T.h. Chan School of Public Health
Statistics
Citations: 193
Authors: 9
Affiliations: 3
Identifiers
Doi:
10.1371/journal.pone.0008770
e-ISSN:
19326203
Research Areas
Environmental
Infectious Diseases
Study Design
Cohort Study
Study Locations
Tanzania
Participants Gender
Female