Skip to content
Home
About Us
Resources
Profiles Metrics
Authors Directory
Institutions Directory
Top Authors
Top Institutions
Top Sponsors
AI Digest
Contact Us
Menu
Home
About Us
Resources
Profiles Metrics
Authors Directory
Institutions Directory
Top Authors
Top Institutions
Top Sponsors
AI Digest
Contact Us
Home
About Us
Resources
Profiles Metrics
Authors Directory
Institutions Directory
Top Authors
Top Institutions
Top Sponsors
AI Digest
Contact Us
Menu
Home
About Us
Resources
Profiles Metrics
Authors Directory
Institutions Directory
Top Authors
Top Institutions
Top Sponsors
AI Digest
Contact Us
Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
medicine
Nuclear β-catenin expression as a prognostic factor in advanced colorectal carcinoma
World Journal of Gastroenterology, Volume 14, No. 24, Year 2008
Notification
URL copied to clipboard!
Description
Aim: To investigate the changing pattern of β-catenin expression and its prognostic value in advanced colorectal cancer (CRC). Methods: Archival tumor samples were analyzed for β-catenin using immunohistochemistry (IHC) in 95 patients with advanced CRC. Results: Membranous β-catenin expression was found in the normal colorectal epithelium. Almost 100% of CRC cases showed membranous and cytoplasmic expression, and 55 (58%) cases showed nuclear expression. In univariate (Kaplan-Meier) survival analysis, only the nuclear index (NI) was a significant predictor of disease-free survival (DFS) (P = 0.023; n = 35), with a NI above the median associated with longer DFS (34.2 mo) than those with a NI below the median (15.5 mo) (P = 0.045, ANOVA). The other indices were not significant predictors of DFS, and none of the three tested indices (for membranous, cytoplasmic, or nuclear expression) predicted disease-specific survival (DSS). However, when dichotomized as positive or negative nuclear expression, the former was a significant predictor of more favorable DFS (P = 0.041) and DSS (P = 0.046). Conclusion: Nuclear β-catenin expression provides additional information in predicting patient outcome in advanced CRC. © 2008 The WJG Press. All rights reserved.
Authors & Co-Authors
Elzagheid, Adam Ibrahim
Finland, Turku
Turun Yliopisto
Libya, Benghazi
Al Arab Medical University
Buhmeida, Abdelbaset
Finland, Turku
Turun Yliopistollinen Keskussairaala
Korkeila, Eija Annika
Finland, Turku
Turun Yliopistollinen Keskussairaala
Collãn, Yrjöu Urho Ilmari
Finland, Turku
Turun Yliopisto
Syrjänen, Kari Juhani
Finland, Turku
Turun Yliopistollinen Keskussairaala
Pyrhönen, Seppo Olavi
Finland, Turku
Turun Yliopistollinen Keskussairaala
Statistics
Citations: 53
Authors: 6
Affiliations: 3
Identifiers
Doi:
10.3748/wjg.14.3866
ISSN:
10079327
Research Areas
Cancer
Health System And Policy