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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
biochemistry, genetics and molecular biology
Heat shock protein 27 expression in the human testis showing normal and abnormal spermatogenesis
Cell Biology International, Volume 32, No. 10, Year 2008
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Description
Heat shock proteins (HSPs) are molecular chaperones involved in protein folding, assembly and transport, and which play critical roles in the regulation of cell growth, survival and differentiation. We set out to test the hypothesis that HSP27 protein is expressed in the human testes and its expression varies with the state of spermatogenesis. HSP27 expression was examined in 30 human testicular biopsy specimens (normal spermatogenesis, maturation arrest and Sertoli cell only syndrome, 10 cases each) using immunofluorescent methods. The biopsies were obtained from patients undergoing investigations for infertility. The seminiferous epithelium of the human testes showing normal spermatogenesis had a cell type-specific expression of HSP27. HSP27 expression was strong in the cytoplasm of the Sertoli cells, spermatogonia, and Leydig cells. Alternatively, the expression was moderate in the spermatocytes, weak in the spermatids and absent in the spermatozoa. In testes showing maturation arrest, HSP27 expression was strong in the Sertoli cells, weak in the spermatogonia, and spermatocytes. It was absent in the spermatids and Leydig cells. In Sertoli cell only syndrome, HSP27 expression was strong in the Sertoli cells and absent in the Leydig cells. We report for the first time the expression patterns of HSP27 in the human testes and show differential expression during normal spermatogenesis, indicating a possible role in this process. The altered expression of this protein in testes showing abnormal spermatogenesis may be related to the pathogenesis of male infertility. © 2008 International Federation for Cell Biology.
Authors & Co-Authors
Adly, Mohamed Arafa
Egypt, Sohag
Faculty of Science
Saudi Arabia, Abha
King Khalid University
Assaf, Hanan Abdel Rady
Egypt, Sohag
Sohag University
Hussein, Mahmoud Rezk Abdelwahed
Egypt, Asyut
Faculty of Veterinary Medicine
Saudi Arabia, Abha
Assir Central Hospital
Statistics
Citations: 26
Authors: 3
Affiliations: 5
Identifiers
Doi:
10.1016/j.cellbi.2008.07.009
ISSN:
10656995
Research Areas
Sexual And Reproductive Health
Participants Gender
Male