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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
general
Schizophrenia-associated mt-DNA SNPs exhibit highly variable haplogroup affiliation and nuclear ancestry: Bi-genomic dependence raises major concerns for link to disease
PLoS ONE, Volume 13, No. 12, Article e0208828, Year 2018
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Description
Mitochondria play a significant role in human diseases. However, disease associations with mitochondrial DNA (mtDNA) SNPs have proven difficult to replicate. An analysis of eight schizophrenia-associated mtDNA SNPs, in 23,743 Danes without a psychiatric diagnosis and 2,538 schizophrenia patients, revealed marked inter-allelic differences in mitochondrial haplogroup affiliation and nuclear ancestry. This bi-genomic dependence could entail population stratification. Only two mitochondrial SNPs, m.15043A and m.15218G, were significantly associated with schizophrenia. However, these associations disappeared when corrected for haplogroup affiliation and nuclear ancestry. The extensive bi-genomic dependence documented here is a major concern when interpreting historic, as well as designing future, mtDNA association studies. © 2018 Hagen et al. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
Available Materials
https://efashare.b-cdn.net/share/pmc/articles/PMC6287820/bin/pone.0208828.s001.docx
https://efashare.b-cdn.net/share/pmc/articles/PMC6287820/bin/pone.0208828.s002.tif
https://efashare.b-cdn.net/share/pmc/articles/PMC6287820/bin/pone.0208828.s003.tif
Authors & Co-Authors
Hagen, Christian Munch
Denmark, Copenhagen
Statens Serum Institut
Hedley, P. L.
Denmark, Copenhagen
Statens Serum Institut
Bybjerg-Grauholm, Jonas
Denmark, Copenhagen
Statens Serum Institut
Baekvad-Hansen, Marie
Denmark, Copenhagen
Statens Serum Institut
Hansen, Christine Soholm
Denmark, Copenhagen
Statens Serum Institut
Kanters, Jörgen Kim
Denmark, Copenhagen
Københavns Universitet
Nielsen, Jimmi R.
Denmark, Aalborg
Aalborg Universitetshospital
Mors, Ole N.
Denmark, Aarhus
Aarhus Universitet
Als, Thomas Damm
Denmark, Aarhus
Aarhus Universitet
Nordentoft, Merete
Unknown Affiliation
BØRglum, Anders Dupont
Denmark, Aarhus
Aarhus Universitet
Mortensen, Preben Bo
Denmark, Aarhus
Aarhus Universitet
Kennedy, James Lowery
Canada, Toronto
Centre for Addiction and Mental Health
Werge, Thomas M.
Unknown Affiliation
Hougaard, David Michael
Denmark, Copenhagen
Statens Serum Institut
Christiansen, Michael
Denmark, Copenhagen
Statens Serum Institut
Denmark, Copenhagen
Københavns Universitet
Statistics
Citations: 8
Authors: 16
Affiliations: 5
Identifiers
Doi:
10.1371/journal.pone.0208828
ISSN:
19326203
Research Areas
Cancer
Genetics And Genomics
Health System And Policy
Mental Health
Study Design
Cross Sectional Study