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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
medicine
Diagnostic yield of endoscopic retrograde cholangiography and of EUS-guided fine needle aspiration sampling in gallbladder carcinomas
Journal of Hepato-Biliary-Pancreatic Sciences, Volume 19, No. 6, Year 2012
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Description
Background Obtaining histological evidence of gallbladder carcinoma (GBC) is difficult due to its extraductal nature, and pathological confirmation remains challenging. We compared the diagnostic value and safety of endoscopic ultrasound-guided fine-needle aspiration (EUSFNA) with endoscopic retrograde cholangiography (ERC) in patients with suspected GBC. Patients Eighty-three patients with GBC were evaluated. Prior to definitive management, pathological evidence of GBC was obtained through either ERC cytopathologic sampling (n = 33), EUS-FNA (n = 24) or both (n = 26). Results Among the 83 patients, 59 (71.0%) with biliary obstruction were sampled using ERC with 47.4% (28/59) sensitivity. In 19 of the remaining 31 cases, EUS-FNA sampling had 100% diagnostic sensitivity. Likewise, 50 (60.2%) of the 83 patients with suspected GBC underwent EUS-FNA of regional lymph nodes or the gallbladder (GB) mass itself with 94.8% sensitivity. The overall diagnostic sensitivity rates of ERC and EUS-FNA were 47.4 and 96%, respectively (P<0.001). Post-procedural complications were seen in 6.7% of the ERC group (4/59, all were mild pancreatitis), and in none of the EUS-FNA group (P = 0.10). Conclusions Gallbladder carcinoma sampling using ERC and EUS-FNA should be incorporated into the diagnostic workup of GB lesions as complementary tools, and EUSFNA should be applied in the setting of failed or not indicated ERC. © Japanese Society of Hepato-Biliary-Pancreatic Surgery and Springer 2011.
Authors & Co-Authors
Hijioka, Susumu
Japan, Nagoya
Aichi Cancer Center Hospital and Research Institute
Hara, Kazuo
Japan, Nagoya
Aichi Cancer Center Hospital and Research Institute
Mizuno, Nobumasa
Japan, Nagoya
Aichi Cancer Center Hospital and Research Institute
Imaoka, Hiroshi
Japan, Nagoya
Aichi Cancer Center Hospital and Research Institute
Ogura, Takeshi
Japan, Nagoya
Aichi Cancer Center Hospital and Research Institute
Haba, Shin
Japan, Nagoya
Aichi Cancer Center Hospital and Research Institute
Mekky, M. A.
Egypt, Asyut
Faculty of Medicine
Bhatia, Vikram K.
India, New Delhi
Institute of Liver and Biliary Sciences
Hosoda, Waki
Japan, Nagoya
Aichi Cancer Center Hospital and Research Institute
Yatabe, Yasushi
Japan, Nagoya
Aichi Cancer Center Hospital and Research Institute
Shimizu, Yashuhiro
Japan, Nagoya
Aichi Cancer Center Hospital and Research Institute
Niwa, Yasumasa
Japan, Nagoya
Aichi Cancer Center Hospital and Research Institute
Tajika, Masahiro
Japan, Nagoya
Aichi Cancer Center Hospital and Research Institute
Kondo, Shinya
Japan, Nagoya
Aichi Cancer Center Hospital and Research Institute
Tanaka, Tsutomu
Japan, Nagoya
Aichi Cancer Center Hospital and Research Institute
Tamada, Kiichi
Japan, Kawachi District
Jichi Medical University
Yamao, Kenji
Japan, Nagoya
Aichi Cancer Center Hospital and Research Institute
Statistics
Citations: 35
Authors: 17
Affiliations: 4
Identifiers
Doi:
10.1007/s00534-011-0482-6
ISSN:
18686974
e-ISSN:
18686982
Research Areas
Cancer
Health System And Policy