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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
biochemistry, genetics and molecular biology
Differential var gene expression in the organs of patients dying of falciparum malaria
Molecular Microbiology, Volume 65, No. 4, Year 2007
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Description
Sequestration of parasitized erythrocytes in the microcirculation of tissues is thought to be important in the pathogenesis of severe falciparum malaria. A major variant surface antigen, var/Plasmodium falciparum erythrocyte membrane protein 1, expressed on the surface of the infected erythrocyte, mediates cytoadherence to vascular endothelium. To address the question of tissue-specific accumulation of variant types, we used the unique resource generated by the clinicopathological study of fatal paediatric malaria in Blantyre, Malawi, to analyse var gene transcription in patients dying with falciparum malaria. Despite up to 102 different var genes being expressed by P. falciparum populations in a single host, only one to two of these genes were expressed at high levels in the brains and hearts of these patients. These major var types differed between organs. However, identical var types were expressed in the brains of multiple patients from a single malaria season. These results provide the first evidence of organ-specific accumulation of P. falciparum variant types and suggest that parasitized erythrocytes can exhibit preferential binding in the body, supporting the hypothesis of cytoadherence-linked pathogenesis. © 2007 Liverpool School of Tropical Medicine.
Available Materials
https://efashare.b-cdn.net/share/pmc/articles/PMC2170262/bin/mmi0065-0959-SD1.pdf
Authors & Co-Authors
Montgomery, Jacqui L.
Malawi, Zomba
University of Malawi
United Kingdom, Liverpool
Liverpool School of Tropical Medicine
Mphande, Fingani A.
Malawi, Zomba
University of Malawi
Sweden, Solna
Department of Microbiology, Tumor and Cell Biology
Berriman, Matthew
United Kingdom, Hinxton
Wellcome Sanger Institute
Pain, Arnab P.
United Kingdom, Hinxton
Wellcome Sanger Institute
Rogerson, Stephen J.
Australia, Melbourne
University of Melbourne
Taylor, Terrie Ellen
Malawi, Blantyre
Blantyre Malaria Project
United States, East Lansing
Msu College of Osteopathic Medicine
Molyneux, Malcolm Edward
Malawi, Zomba
University of Malawi
United Kingdom, Liverpool
Liverpool School of Tropical Medicine
Craig, Alister Gordon
United Kingdom, Liverpool
Liverpool School of Tropical Medicine
Statistics
Citations: 77
Authors: 8
Affiliations: 7
Identifiers
Doi:
10.1111/j.1365-2958.2007.05837.x
ISSN:
0950382X
e-ISSN:
13652958
Research Areas
Genetics And Genomics
Health System And Policy
Infectious Diseases
Study Locations
Malawi