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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
agricultural and biological sciences
Clade-specific evolution mediated by HLA-B*57/5801 in human immunodeficiency virus type 1 clade A1 p24
Journal of Virology, Volume 83, No. 23, Year 2009
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Description
HLA-B*57-mediated selection pressure leads to a typical escape pathway in human immunodeficiency virus type 1 (HIV-1) CD8 epitopes such as TW10. Whether this T242N pathway is shared by all clades remains unknown. We therefore assessed the nature of HLA-B*57 selection in a large, observational Kenyan cohort where clades A1 and D predominate. While T242N was ubiquitous in clade D HLA-B*57+ subjects, this mutation was rare (15%) in clade A1. Instead, P243T and I247L were selected by clade A1-infected HLA-B*57 subjects but not by HLA-B*5801+ subjects. Our data suggest that clade A1 consensus proline at Gag residue 243 might represent an inherent block to T242N escape in clade A1. We confirmed immunologically that P243T and I247L likely represent escape mutations. HLA-B*57 evolution also differed between clades in the KF11 and IW9 epitopes. A better understanding of clade-specific evolution is important for the development of HIV vaccines in regions with multiple clades. Copyright © 2009, American Society for Microbiology. All Rights Reserved.
Authors & Co-Authors
McKinnon, Lyle R.
Canada, Winnipeg
University of Manitoba
Kenya, Nairobi
University of Nairobi
Capiña, Rupert
Canada, Winnipeg
National Microbiology Laboratory
Peters, Harold O.
Canada, Winnipeg
National Microbiology Laboratory
Mendoza, Mark G.R.
Canada, Winnipeg
National Microbiology Laboratory
Kimani, Joshua
Canada, Winnipeg
University of Manitoba
Kenya, Nairobi
University of Nairobi
Wachihi, Charles
Kenya, Nairobi
University of Nairobi
Kariri, Anthony
Kenya, Nairobi
University of Nairobi
Kimani, Makobu
Kenya, Nairobi
University of Nairobi
Richmond, Meika E.I.
Canada, Winnipeg
University of Manitoba
Kiazyk, Sandra A.Koesters
Canada, Ottawa
Public Health Agency of Canada
Fowke, Keith Raymond
Canada, Winnipeg
University of Manitoba
Kenya, Nairobi
University of Nairobi
Jaoko, Walter G.
Kenya, Nairobi
University of Nairobi
Luo, Ma
Canada, Winnipeg
National Microbiology Laboratory
Ball, Terry Blake
Canada, Winnipeg
University of Manitoba
Kenya, Nairobi
University of Nairobi
Canada, Ottawa
Public Health Agency of Canada
Plummer, Francis Allan
Canada, Winnipeg
University of Manitoba
Kenya, Nairobi
University of Nairobi
Canada, Winnipeg
National Microbiology Laboratory
Canada, Ottawa
Public Health Agency of Canada
Statistics
Citations: 15
Authors: 15
Affiliations: 4
Identifiers
Doi:
10.1128/JVI.01236-09
ISSN:
0022538X
Research Areas
Cancer
Infectious Diseases
Study Design
Cohort Study