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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
Design, synthesis and in vivo anti-inflammatory activities of 2,4-diaryl-5-4H-imidazolone derivatives
Molecules, Volume 17, No. 10, Year 2012
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Description
A series of 2,4-diaryl-5(4H)-imidazolones were prepared and evaluated for their anti-inflammatory activities. Some selected 2,4-diaryl-5(4H)-imidazolones exhibited excellent anti-inflammatory activity in the carrageenan-induced rat paw edema model. Structure Activity Relationships within the series were studied. The substitution at the N-sulfonamide moiety by a small hydrophilic acetyl group resulted in compounds with superior in vivo anti-inflammatory properties. As expected from their COX-2 selectivity, most of the active compounds lacked gastrointestinal toxicity in vivo in rats after a 3-day treatment of 25 mg/kg/day. © 2012 by the authors; licensee MDPI, Basel, Switzerland.
Authors & Co-Authors
El-Araby, Moustafa E.
Egypt, Helwan
Faculty of Pharmacy
Saudi Arabia, Jeddah
King Abdulaziz University
Omar, Abdelsattar M.
Saudi Arabia, Jeddah
King Abdulaziz University
Egypt, Cairo
Faculty of Pharmacy
Hassanein, Hassanein H.
Egypt, Cairo
Faculty of Pharmacy
El-Helby, Abdel Ghany Aly
Egypt, Cairo
Faculty of Pharmacy
Abdel-Rahman, Asharf A.
Egypt, Cairo
Faculty of Pharmacy
Statistics
Citations: 37
Authors: 5
Affiliations: 4
Identifiers
Doi:
10.3390/molecules171012262
e-ISSN:
14203049