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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
biochemistry, genetics and molecular biology
First report of prevalence of non-syndromic hereditary prosopagnosia (HPA)
American Journal of Medical Genetics, Part A, Volume 140, No. 15, Year 2006
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Description
Acquired prosopagnosia (PA) is a rare condition after, for example, a stroke or brain injury. The congenital form of PA is generally considered to be even less common. Beside a few single case reports and anecdotal mentioning of familial cases no data on the epidemiology exists. Following a questionnaire-based screening in local secondary schools and at our medical faculty, candidates suspicious for PA underwent a semi-structured interview followed by examinations of first degree relatives. Among 689 local pupils and medical students of our university we found 17 with congenital PA. This corresponds to a prevalence rate of 2.47% (95% CI 1.31-3.63). The frequency is among the highest known for a monogenic disorder. All those index subjects (n = 14) of the target group who agreed to further examinations of their family members had other first degree relatives with the same cognitive disorder. This study provides epidemiological evidence that congenital PA is a very common cognitive disorder which almost always runs in families. The segregation pattern of this hereditary prosopagnosia (HPA) is fully compatible with autosomal dominant inheritance. © 2006 Wiley-Liss, Inc.
Authors & Co-Authors
Kennerknecht, Ingo
Germany, Munster
University of Münster
Grueter, Thomas
Germany, Munster
Nottulner Landweg
Welling, Brigitte
Germany, Munster
University of Münster
Wentzek, Sebastian
Germany, Munster
University of Münster
Horst, Juergen
Germany, Munster
University of Münster
Edwards, Steve
South Africa, Ulundi
University of Zululand
Grueter, Martina
Germany, Munster
University of Münster
Statistics
Citations: 236
Authors: 7
Affiliations: 3
Identifiers
Doi:
10.1002/ajmg.a.31343
ISSN:
15524825
e-ISSN:
15524833
Research Areas
Noncommunicable Diseases
Violence And Injury
Study Design
Cross Sectional Study
Case Study