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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
medicine
Increases in CSF dopamine in HIV patients are due to the dopamine transporter 10/10-repeat allele which is more frequent in HIV-infected individuals
Journal of Neural Transmission, Volume 120, No. 10, Year 2013
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Description
Dysfunction of dopaminergic neurotransmission has been implicated in HIV infection. We showed previously increased dopamine (DA) levels in CSF of therapy-naïve HIV patients and an inverse correlation between CSF DA and CD4 counts in the periphery, suggesting adverse effects of high levels of DA on HIV infection. In the current study including a total of 167 HIV-positive and negative donors from Germany and South Africa (SA), we investigated the mechanistic background for the increase of CSF DA in HIV individuals. Interestingly, we found that the DAT 10/10-repeat allele is present more frequently within HIV individuals than in uninfected subjects. Logistic regression analysis adjusted for gender and ethnicity showed an odds ratio for HIV infection in DAT 10/10 allele carriers of 3.93 (95 % CI 1.72-8.96; p = 0.001, Fishers exact test). 42.6 % HIV-infected patients harbored the DAT 10/10 allele compared to only 10.5 % uninfected DAT 10/10 carriers in SA (odds ratio 6.31), whereas 68.1 versus 40.9 %, respectively, in Germany (odds ratio 3.08). Subjects homozygous for the 10-repeat allele had higher amounts of CSF DA and reduced DAT mRNA expression but similar disease severity compared with those carrying other DAT genotypes. These intriguing and novel findings show the mutual interaction between DA and HIV, suggesting caution in the interpretation of CNS DA alterations in HIV infection solely as a secondary phenomenon to the virus and open the door for larger studies investigating consequences of the DAT functional polymorphism on HIV epidemiology and progression of disease. © 2013 The Author(s).
Authors & Co-Authors
Horn, Anne
Germany, Wurzburg
Julius-maximilians-universität Würzburg
Scheller, Carsten
Germany, Wurzburg
Julius-maximilians-universität Würzburg
Du Plessis, Stéfan
South Africa, Stellenbosch
Stellenbosch University
Arendt, Gabriele
Germany, Dusseldorf
Universitätsklinikum Düsseldorf
Nolting, Thorsten
Germany, Dusseldorf
Universitätsklinikum Düsseldorf
Joska, John A.
South Africa, Cape Town
University of Cape Town
Sopper, Sieghart
Austria, Innsbruck
Medizinische Universitat Innsbruck
Maschke, Matthias
Germany, Essen
Universitätsklinikum Essen
Obermann, Mark
Germany, Essen
Universitätsklinikum Essen
Husstedt, Ingo Wilhelm
Germany, Munster
Universitätsklinikum Münster
Hain, Johannes
Germany, Wurzburg
Julius-maximilians-universität Würzburg
Maponga, Tongai G.
South Africa, Stellenbosch
Stellenbosch University
Riederer, Peter Franz
Germany, Wurzburg
Julius-maximilians-universität Würzburg
Koutsilieri, Eleni
Germany, Wurzburg
Julius-maximilians-universität Würzburg
Statistics
Citations: 23
Authors: 14
Affiliations: 7
Identifiers
Doi:
10.1007/s00702-013-1086-x
ISSN:
03009564
e-ISSN:
14351463
Research Areas
Genetics And Genomics
Infectious Diseases
Study Design
Case-Control Study
Study Approach
Quantitative
Study Locations
South Africa