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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
medicine
Vaccination-induced cutaneous pseudolymphoma
Journal of the American Academy of Dermatology, Volume 52, No. 4, Year 2005
Notification
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Description
Background: Although mild early cutaneous transient reactions to vaccinations are common, late-onset chronic lesions have been scarcely reported. We report herein a series of 9 patients presenting with cutaneous and subcutaneous pseudolymphoma. Observations: Nine patients presenting with late-onset, chronic skin lesions occurring at the site of antihepatitis B (8 cases) and antihepatitis A (one case) vaccination were reported. Histopathologic and immunohistochemic studies, and molecular analysis of clonality of skin biopsy specimens, were performed. Furthermore, the presence of vaccine products was investigated in skin lesions by using histochemical, microanalytic, and electronic microscopy techniques. Results: Histopathologic studies showed dermal and hypodermal lymphocytic follicular infiltrates with germinal center formation. The center of follicles was mostly composed of B cells without atypia, whereas CD4+ T cells were predominant at the periphery. Molecular analysis of clonality revealed a polyclonal pattern of B-cell and T-cell subsets. Aluminium deposits were evidenced in all cases by using histochemical staining in all cases, and by microanalysis and ultrastructural studies in one case. Associated manifestations were vitiligo (one case) and chronic fatigue with myalgia (two cases). Conclusion: Cutaneous lymphoid hyperplasia is a potential adverse effect of vaccinations including aluminium hydroxide as an adjuvant. Further prospective studies are warranted to evaluate the incidence of this complication in the immunized population. © 2005 by the American Academy of Dermatology, Inc.
Authors & Co-Authors
Maubec, Ève
France, Paris
Institut de Recherche Sur la Peau
Pinquier, Laure
France, Paris
Laboratoire D'anatomie Pathologique
Viguier, Manuelle Anne
France, Paris
Institut de Recherche Sur la Peau
Caux, Frédéric A.
France, Bobigny
Hopital Avicenne
Amsler, Emmanuelle
France, Paris
Hôpital Saint-louis
Aractingi, Sélim
France, Paris
Hôpital Saint-louis
Chafi, Hafid
Morocco, Oujda
Université Mohammed Premier Oujda
Janin, Anne
France, Paris
Laboratoire D'anatomie Pathologique
Cayuela, Jean Michel
France, Paris
Laboratoire D'hématologie
Dubertret, Louis
France, Paris
Institut de Recherche Sur la Peau
Authier, François Jérôme
France, Creteil
Hôpital Henri Mondor
Bachelez, Hervé
France, Paris
Institut de Recherche Sur la Peau
France, Paris
Hôpital Saint-louis
Statistics
Citations: 89
Authors: 12
Affiliations: 7
Identifiers
Doi:
10.1016/j.jaad.2004.12.021
ISSN:
01909622
Study Design
Cross Sectional Study
Cohort Study