Skip to content
Home
About Us
Resources
Profiles Metrics
Authors Directory
Institutions Directory
Top Authors
Top Institutions
Top Sponsors
AI Digest
Contact Us
Menu
Home
About Us
Resources
Profiles Metrics
Authors Directory
Institutions Directory
Top Authors
Top Institutions
Top Sponsors
AI Digest
Contact Us
Home
About Us
Resources
Profiles Metrics
Authors Directory
Institutions Directory
Top Authors
Top Institutions
Top Sponsors
AI Digest
Contact Us
Menu
Home
About Us
Resources
Profiles Metrics
Authors Directory
Institutions Directory
Top Authors
Top Institutions
Top Sponsors
AI Digest
Contact Us
Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
medicine
Haptoglobin, alpha-thalassaemia and glucose-6-phosphate dehydrogenase polymorphisms and risk of abnormal transcranial Doppler among patients with sickle cell anaemia in Tanzania
British Journal of Haematology, Volume 165, No. 5, Year 2014
Notification
URL copied to clipboard!
Description
Transcranial Doppler ultrasonography measures cerebral blood flow velocity (CBFv) of basal intracranial vessels and is used clinically to detect stroke risk in children with sickle cell anaemia (SCA). Co-inheritance in SCA of alpha-thalassaemia and glucose-6-phosphate dehydrogenase (G6PD) polymorphisms is reported to associate with high CBFv and/or risk of stroke. The effect of a common functional polymorphism of haptoglobin (HP) is unknown. We investigated the effect of co-inheritance of these polymorphisms on CBFv in 601 stroke-free Tanzanian SCA patients aged <24 years. Homozygosity for alpha-thalassaemia 3·7 deletion was significantly associated with reduced mean CBFv compared to wild-type (β-coefficient -16·1 cm/s, P = 0·002) adjusted for age and survey year. Inheritance of 1 or 2 alpha-thalassaemia deletions was associated with decreased risk of abnormally high CBFv, compared to published data from Kenyan healthy control children (Relative risk ratio [RRR] = 0·53 [95% confidence interval (CI):0·35-0·8] & RRR = 0·43 [95% CI:0·23-0·78]), and reduced risk of abnormally low CBFv for 1 deletion only (RRR = 0·38 [95% CI:0·17-0·83]). No effects were observed for G6PD or HP polymorphisms. This is the first report of the effects of co-inheritance of common polymorphisms, including the HP polymorphism, on CBFv in SCA patients resident in Africa and confirms the importance of alpha-thalassaemia in reducing risk of abnormal CBFv. © 2014 The Authors. British Journal of Haematology Published by John Wiley & Sons Ltd.
Available Materials
https://efashare.b-cdn.net/share/pmc/articles/PMC4154124/bin/bjh-165-699-s1.doc
Authors & Co-Authors
Cox, Sharon E.
United Kingdom, London
Medical Research Council
Tanzania, Dar es Salaam
Muhimbili University of Health and Allied Sciences
Makani, Julie B.
Tanzania, Dar es Salaam
Muhimbili University of Health and Allied Sciences
United Kingdom, Oxford
Nuffield Department of Medicine
Soka, Deogratias
Tanzania, Dar es Salaam
Muhimbili University of Health and Allied Sciences
L’Esperance, Veline S.
United Kingdom, Southampton
University of Southampton, Faculty of Medicine
Kija, Edward
Tanzania, Dar es Salaam
Muhimbili University of Health and Allied Sciences
Domínguez-Salas, Paula
United Kingdom, London
Medical Research Council
Newton, Charles R.J.C.
Tanzania, Dar es Salaam
Muhimbili University of Health and Allied Sciences
United Kingdom, Oxford
University of Oxford
Kenya, Kilifi
Centre for Geographic Medicine Research
Birch, Anthony
United Kingdom, Southampton
University Hospital Southampton Nhs Foundation Trust
Prentice, Andrew M.
United Kingdom, London
Medical Research Council
Kirkham, Fenella Jane
United Kingdom, London
Ucl Great Ormond Street Institute of Child Health
Statistics
Citations: 52
Authors: 10
Affiliations: 8
Identifiers
Doi:
10.1111/bjh.12791
ISSN:
00071048
e-ISSN:
13652141
Research Areas
Maternal And Child Health
Noncommunicable Diseases
Study Design
Cross Sectional Study
Study Approach
Quantitative
Study Locations
Tanzania