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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
general
Seroprevalence of SARS-CoV-2 IgG among healthcare workers in Lagos, Nigeria
PLoS ONE, Volume 18, No. 10 October, Article e0292440, Year 2023
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Description
Healthcare workers (HCWs) are disproportionately infected with SARS-CoV-2 when compared to members of the general public; estimating the seroprevalence of SARS-CoV-2 antibody and SARS-CoV-2 infection rate among HCWs is therefore crucial. This study was carried out in four health facilities in Lagos Nigeria to determine the prevalence of IgG antibodies (seroprevalence) and SARS-CoV-2 active infection rate via a positive rtPCR result, the cross-sectional study was conducted between December 2020 and July 2021. Nasopharyngeal and blood samples were collected from HCWs and screened for SARS-CoV-2 infection using the rtPCR technique and antibody using the Abbott anti-SARS-CoV-2 IgG CMIA assay, respectively. Demographic and occupational exposures data were obtained and analysed using descriptive and inferential statistics, variables significant via inferential statistics were subjected to a multivariate analysis. A total of 413 participants were enrolled, with a mean age in years of 38.4±11.0. The seroprevalence was 30.9% (115/372) while 63/ 395 (15.9%) were actively infected with the virus. HCWs whose job role had direct contact with patients had a higher percentage of SARS-CoV-2 infection when compared with those not in direct contact, also being a health care worker was significantly associated with getting a positive COVID-19 PCR result. In conclusion the SARS-CoV-2 seroprevalence seen in this study was higher than national serosurvey estimates indicating HCWs are at higher risk of COVID-19 infection when compared to the general public. Vaccination and effective implementation of infection control measures are important to protect HCWs. Copyright: © 2023 Ige et al. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
Authors & Co-Authors
Ige, Fehintola Anthonia
Nigeria, Yaba
Nigerian Institute of Medical Research
Ohihoin, Greg Aigbe
Nigeria, Yaba
Nigerian Institute of Medical Research
Osuolale, Kazeem Adewale
Nigeria, Yaba
Nigerian Institute of Medical Research
Dada, Adedamola A.
Nigeria
Federal Medical Centre Nigeria
Onyia, Ngozi O.
Nigeria, Lagos
Paelon Memorial Hospital
Johnson, Adeyemi
Nigeria, Lagos
First Cardiology Consultants Hospital Ikoyi
Okwuraiwe, Azuka Patrick
Nigeria, Yaba
Nigerian Institute of Medical Research
Odediran, Omoladun Olukemi
Nigeria, Lagos
University of Lagos
Liboro, Gideon Odemakpore
Nigeria, Yaba
Nigerian Institute of Medical Research
Aniedobe, Maureen
Nigeria, Yaba
Nigerian Institute of Medical Research
Mogaji, Sunday
Nigeria
Federal Medical Centre Nigeria
Nwaiwu, Stephanie Ogechi
Nigeria, Yaba
Nigerian Institute of Medical Research
Audu, Rosemary Ajuma
Nigeria, Yaba
Nigerian Institute of Medical Research
Salako, Babatunde Lawal
Nigeria, Yaba
Nigerian Institute of Medical Research
Statistics
Authors: 14
Affiliations: 5
Identifiers
Doi:
10.1371/journal.pone.0292440
ISSN:
19326203
Research Areas
Covid
Health System And Policy
Study Design
Cross Sectional Study
Study Approach
Quantitative
Study Locations
Nigeria