Skip to content
Home
About Us
Resources
Profiles Metrics
Authors Directory
Institutions Directory
Top Authors
Top Institutions
Top Sponsors
AI Digest
Contact Us
Menu
Home
About Us
Resources
Profiles Metrics
Authors Directory
Institutions Directory
Top Authors
Top Institutions
Top Sponsors
AI Digest
Contact Us
Home
About Us
Resources
Profiles Metrics
Authors Directory
Institutions Directory
Top Authors
Top Institutions
Top Sponsors
AI Digest
Contact Us
Menu
Home
About Us
Resources
Profiles Metrics
Authors Directory
Institutions Directory
Top Authors
Top Institutions
Top Sponsors
AI Digest
Contact Us
Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
medicine
Brain haemosiderin in older people: Pathological evidence for an ischaemic origin of magnetic resonance imaging (MRI) microbleeds
Neuropathology and Applied Neurobiology, Volume 40, No. 3, Year 2014
Notification
URL copied to clipboard!
Description
Introduction: Magnetic resonance imaging (MRI) cerebral microbleeds (CMB) arise from ferromagnetic haemosiderin iron assumed to derive from extravasation of erythrocytes. Light microscopy of ageing brain frequently reveals foci of haemosiderin from single crystalloids to larger, predominantly perivascular, aggregates. The pathological and radiological relationship between these findings is not resolved. Methods: Haemosiderin deposition and vascular pathology in the putamen were quantified in 200 brains donated to the population-representative Medical Research Council Cognitive Function and Ageing Study. Molecular markers of gliosis and tissue integrity were assessed by immunohistochemistry in brains with highest (n=20) and lowest (n=20) levels of putamen haemosiderin. The association between haemosiderin counts and degenerative and vascular brain pathology, clinical data, and the haemochromatosis (HFE) gene H63D genotype were analysed. The frequency of MRI CMB in 10 cases with highest and lowest burden of putamen haemosiderin, was compared using post mortem 3T MRI. Results: Greater putamen haemosiderin was significantly associated with putaminal indices of small vessel ischaemia (microinfarcts, P<0.05; arteriolosclerosis, P<0.05; perivascular attenuation, P<0.001) and with lacunes in any brain region (P<0.023) but not large vessel disease, or whole brain measures of neurodegenerative pathology. Higher levels of putamen haemosiderin correlated with more CMB (P<0.003). Conclusions: The MRI-CMB concept should take account of brain iron homeostasis, and small vessel ischaemic change in later life, rather than only as a marker for minor episodes of cerebrovascular extravasation. These data are of clinical relevance, suggesting that basal ganglia MRI microbleeds may be a surrogate for ischaemic small vessel disease rather than exclusively a haemorrhagic diathesis. © 2013 The Authors. Neuropathology and Applied Neurobiology published by John Wiley & Sons Ltd on behalf of British Neuropathological Society.
Authors & Co-Authors
Janaway, B. M.
United Kingdom, Sheffield
The Sheffield Medical School
Simpson, J. E.
United Kingdom, Sheffield
The Sheffield Medical School
Hoggard, Nigel
United Kingdom, Sheffield
The University of Sheffield
Highley, Robin Robin
United Kingdom, Sheffield
The Sheffield Medical School
Forster, G.
United Kingdom, Sheffield
The Sheffield Medical School
Drew, D.
United Kingdom, Sheffield
The Sheffield Medical School
Gebril, Ola H.
Egypt, Giza
National Research Centre
Matthews, Fiona Elaine
United Kingdom, Cambridge
University of Cambridge
Brayne, C. E.G.
United Kingdom, Cambridge
Cambridge Institute of Public Health
Wharton, S. B.
United Kingdom, Sheffield
The Sheffield Medical School
Ince, Paul G.
United Kingdom, Sheffield
The Sheffield Medical School
Statistics
Citations: 71
Authors: 11
Affiliations: 5
Identifiers
Doi:
10.1111/nan.12062
ISSN:
03051846
Research Areas
Genetics And Genomics
Study Design
Cross Sectional Study